Dihydrovindolinine

Base Information

• Chemical Name: Dihydrovindolinine
• CAS No.: 17172-16-6
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45
• Mol file: 17172-16-6.mol

Synonyms:2,20-Cycloaspidospermidine-3-carboxylicacid, methyl ester, (2a,3b,5a,12b,19a,20R)-; Pseudokopsinine(7CI,8CI); (-)-Pseudocopsinine; 14,15-Dihydrovindolinine;6,7-Dihydrovindolinine;6H,13aH-3a,5a-Methano-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid,2,3,4,5,11,12-hexahydro-14-methyl-, methyl ester, [3aS-(3aa,5b,5aa,10bS*,13aa,14S*)]-;Dihydrovindolinine; Pseudocopsinine; Pseudoervinine; Pseudokopsinin; y-Kopsinine

Chemical Property of Dihydrovindolinine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: The aerial parts of Vinca erecta yield this imidazolidinocarbazole alkaloid which has been characterized as the epi-base formed on heating with NaOMe in NaOH and giving a crystalline hydrochloride, m.p. 2S7-9°C (dec.); [α]D + 92.1° (MeOH). Treatment of the alkaloid with lead acetate gives the dehydro derivative, m.p. 188-1910C; [α]D + 62° (MeOH).

Technology Process of Dihydrovindolinine

There total 2 articles about Dihydrovindolinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Dihydro-19-epivindolinin (17172-16-6,25343-00-4,55954-33-1)

Guidance literature:

Vindolinin (1), H2, Pd/C;

DOI:10.1016/S0040-4039(01)93205-8

Reference yield:

→ Dihydro-16-epi-vindolinin (17172-16-6,25343-00-4,55954-33-1)

Guidance literature:

16-Epivindolinin (20), H2, Pd/C;

DOI:10.1016/S0040-4039(01)93205-8

Reference yield:

14,15-dihydrovindolinine (17172-16-6,25343-00-4,55954-33-1) → vincadifformine (3247-10-7,6878-14-4,15539-10-3,18374-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine

2: AIBN/PhH/Bu₃SnH / Heating

With 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; benzene;

DOI:10.1016/S0040-4039(01)80732-2

Downstream raw materials:

vincadifformine

Refernces