Technology Process of Benzenepropanoic acid, 2-hydroxy-5-[4-(2-methylpropoxy)benzoyl]-,
methyl ester
There total 10 articles about Benzenepropanoic acid, 2-hydroxy-5-[4-(2-methylpropoxy)benzoyl]-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; sodium formate; acetic acid;
In
water; isopropyl alcohol;
at 45 - 50 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 73 percent / NaClO2; aq. H2O2; NaH2PO4 / acetonitrile / 1 h / 20 °C
2.1: oxalyl chloride; DMF / CH2Cl2 / 1 h / 20 °C
2.2: 80 percent / AlCl3 / CH2Cl2 / 0.5 h / 5 - 10 °C
3.1: 0.55 g / AlCl3 / 1,2-dichloro-ethane / 8 h / Heating
4.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h
4.2: 69 percent / tetrahydrofuran; methanol / 0.5 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; aluminium trichloride; oxalyl dichloride; di-isopropyl azodicarboxylate; dihydrogen peroxide; N,N-dimethyl-formamide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
2.2: Friedel-Crafts reaction / 4.1: Mitsunobu reaction;
DOI:10.1021/jm050550d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: AlCl3 / CH2Cl2 / 1 h / -10 °C
1.2: CH2Cl2 / 2 h / Heating
2.1: 73 percent / NaClO2; aq. H2O2; NaH2PO4 / acetonitrile / 1 h / 20 °C
3.1: oxalyl chloride; DMF / CH2Cl2 / 1 h / 20 °C
3.2: 80 percent / AlCl3 / CH2Cl2 / 0.5 h / 5 - 10 °C
4.1: 0.55 g / AlCl3 / 1,2-dichloro-ethane / 8 h / Heating
5.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h
5.2: 69 percent / tetrahydrofuran; methanol / 0.5 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; aluminium trichloride; oxalyl dichloride; di-isopropyl azodicarboxylate; dihydrogen peroxide; N,N-dimethyl-formamide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
1.1: Friedel-Crafts reaction / 3.2: Friedel-Crafts reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/jm050550d