Technology Process of L-Leucine, 3-hydroxy-, methyl ester, (3S)-
There total 9 articles about L-Leucine, 3-hydroxy-, methyl ester, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 24h;
under 760 Torr;
DOI:10.1021/jo972013+
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; ethyl acetate;
at 20 ℃;
for 24h;
under 760 Torr;
DOI:10.1021/jo0268916
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / (DHQ)2PHAL; K2OsO2(OH)4; K3[Fe(CN)6] / K2CO3; NaHCO3 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 72 h / 5 °C
2: 100 percent / SOCl2; pyridine / CH2Cl2 / cooling
3: 97 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 1.5 h / 20 °C
4: 90 percent / NaN3 / acetone; H2O / 2 h / 20 °C
5: 99 percent / H2 / Pd/C / ethanol; ethyl acetate / 24 h / 20 °C / 760 Torr
With
pyridine; ruthenium trichloride; sodium periodate; thionyl chloride; sodium azide; Hydroquinone 1,4-phthalazinediyl diether; potassium dioxotetrahydroxoosmate(VI); hydrogen; potassium hexacyanoferrate(III);
palladium on activated charcoal; sodium hydrogencarbonate; potassium carbonate;
In
tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; acetone; acetonitrile; tert-butyl alcohol;
1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo0268916
