2-methyl-1-oxo-1-phenylpropan-2-yl acetate

Base Information

• Chemical Name: 2-methyl-1-oxo-1-phenylpropan-2-yl acetate
• CAS No.: 7476-41-7
• Molecular Formula: C12H14 O3
• Molecular Weight: 206.241
• Mol file: 7476-41-7.mol

Synonyms:Propiophenone, 2-hydroxy-2-methyl-, acetate (6CI,8CI);1-Phenyl-2-acetoxy-2-methyl-1-propanone; NSC 401767; a-Acetoxyisobutyrophenone

Chemical Property of 2-methyl-1-oxo-1-phenylpropan-2-yl acetate

Chemical Property:

• Vapor Pressure: 0.00207mmHg at 25°C
• Boiling Point: 290.4°C at 760 mmHg
• Flash Point: 124°C
• Density: 1.082g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-1-oxo-1-phenylpropan-2-yl acetate

There total 19 articles about 2-methyl-1-oxo-1-phenylpropan-2-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(2-methyl-1-phenylprop-1-en-1-yl)acetamide (118284-49-4) → 2-methyl-1-oxo-1-phenylpropan-2-yl acetate (7476-41-7)

Guidance literature:

With dihydrogen peroxide; acetic anhydride; In water; at 20 ℃;

DOI:10.1039/c6ob02002j

Reference yield: 94.0%

2-hydroxy-2-methylpropiophenone (7473-98-5) + acetic anhydride (108-24-7) → 2-methyl-1-oxo-1-phenylpropan-2-yl acetate (7476-41-7)

Guidance literature:

With pyridine; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo901815t

Reference yield: 83.0%

1,3-dioxoisoindolin-2-yl 1-acetoxycyclopentane-1-carboxylate + benzaldehyde (100-52-7) → 2-methyl-1-oxo-1-phenylpropan-2-yl acetate (7476-41-7)

Guidance literature:

With 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/jacs.9b00880

upstream raw materials:

2-bromo-2-methyl-1-phenyl-propan-1-one

potassium acetate

2-methyl-1-phenyl-1-acetoxy-1-propene

acetic acid

Downstream raw materials:

5,5-dimethyl-4-phenyl-5H-furan-2-one

2-methyl-1-phenyl-1-pivaloyloxy-1-propene

phenyl isopropyl ketone

2-hydroxy-2-methylpropiophenone

Refernces

• 1、 Ishii, Takuya,Kakeno, Yuki,Nagao, Kazunori,Ohmiya, Hirohisa. "N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes". supporting information. p. 3854 - 3858. Retrieved 2019/04/25.
• 2、 Zhou, Xiaoqiang,Ma, Haojie,Cao, Jinhui,Liu, Xingxing,Huang, Guosheng. "Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process". supporting information. p. 10070 - 10073. Retrieved 2016/11/06.