3,3-DibroMo Cotinine

Base Information

• Chemical Name: 3,3-DibroMo Cotinine
• CAS No.: 74093-56-4
• Molecular Formula: C10H10Br2N2O
• Molecular Weight: 334.01
• Mol file: 74093-56-4.mol

Synonyms:3,3-Dibromo Cotinine;

Chemical Property of 3,3-DibroMo Cotinine

Chemical Property:

• PSA: 33.20000
• LogP: 2.40880

Purity/Quality:

99%min ^*data from raw suppliers

3,3-DibromoCotinine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3-Dibromo Cotinine is a Cotinine derivative used in the synthesis of 4,4-Ditritio-(+)-nicotine, a nicotine enantiomer binding to brain.

Technology Process of 3,3-DibroMo Cotinine

There total 1 articles about 3,3-DibroMo Cotinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotin (54-11-5) → (S)-3,3-dibromocotinine (74093-56-4)

Guidance literature:

With bromine; acetic acid;

DOI:10.1021/ja01524a034

Reference yield:

(S)-3,3-dibromocotinine (74093-56-4) → cotinine (486-56-6)

Guidance literature:

With hydrogenchloride; acetic acid; zinc;

DOI:10.1021/ja01524a034

Reference yield:

(S)-3,3-dibromocotinine (74093-56-4) → 5-hydroxy-1-methyl-5-(3-pyridyl)-2-pyrrolidinone (61192-50-5,75919-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / KOH / -10 deg C, then 2 h room temperature

2: 82 percent / 15 percent aqueous HBr / 2 h / 95 °C

3: 92 percent / H₂ / 10percent Pd/C / ethyl acetate / 20 h

With potassium hydroxide; hydrogen bromide; hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jo00317a021

upstream raw materials:

nicotin

Downstream raw materials:

cotinine

4-(3-pyridyl)-4-oxo-N-methylbutyramide

5-hydroxy-1-methyl-5-(3-pyridyl)-2-pyrrolidinone