6-amino-5-bromo-N-methylpicolinamide

Base Information

• Chemical Name: 6-amino-5-bromo-N-methylpicolinamide
• CAS No.: 875051-80-2
• Molecular Formula: C₇H₈BrN₃O
• Molecular Weight: 230.064
• Mol file: 875051-80-2.mol

Synonyms:

Chemical Property of 6-amino-5-bromo-N-methylpicolinamide

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-5-bromo-N-methylpicolinamide

There total 7 articles about 6-amino-5-bromo-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methylamine (74-89-5) + 6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester (178876-82-9) → 6-amino-5-bromo-N-methyl-pyridine-2-carboxamide (875051-80-2)

Guidance literature:

In methanol; at 20 ℃; for 18h;

Reference yield:

methyl 5-bromopicolinate (29682-15-3) → 6-amino-5-bromo-N-methyl-pyridine-2-carboxamide (875051-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: silver(II) fluoride / acetonitrile / 1 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube

2: water / 1.5 h / 20 °C / Sealed tube

3: ammonium hydroxide; potassium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Glovebox; Sealed tube

With ammonium hydroxide; silver(II) fluoride; potassium carbonate; In water; dimethyl sulfoxide; acetonitrile;

DOI:10.1021/ja5049303

Reference yield:

C7H6BrFN2O (1616667-62-9) → 6-amino-5-bromo-N-methyl-pyridine-2-carboxamide (875051-80-2)

Guidance literature:

With ammonium hydroxide; potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/ja5049303

upstream raw materials:

methylamine

6-amino-5-bromo-pyridine-2-carboxylic acid methyl ester

methyl 5-bromo-6-fluoropyridine-2-carboxylate

C₇H₆BrFN₂O

Refernces

• 1、 -. "C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE". Paragraph 00167. . Retrieved 2015/02/19.
• 2、 -. "PYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS". Page/Page column 37. . Retrieved 2010/11/28.