Technology Process of Isothiazolo[5,4-d]pyrimidin-4(5H)-one,
6-(1-bromopropyl)-5-[(3-fluorophenyl)methyl]-3-methyl-
There total 7 articles about Isothiazolo[5,4-d]pyrimidin-4(5H)-one,
6-(1-bromopropyl)-5-[(3-fluorophenyl)methyl]-3-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ammonium hydroxide; dihydrogen peroxide / water / 16 h / 60 °C
2: ammonium hydroxide / water / 4 h / 140 °C
3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
4: bromine; sodium acetate; acetic acid / 0.33 h / 100 °C
With
ammonium hydroxide; dihydrogen peroxide; bromine; sodium acetate; potassium carbonate; acetic acid;
In
water; N,N-dimethyl-formamide;
DOI:10.1021/jm200629m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ammonium hydroxide / water / 4 h / 140 °C
2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
3: bromine; sodium acetate; acetic acid / 0.33 h / 100 °C
With
ammonium hydroxide; bromine; sodium acetate; potassium carbonate; acetic acid;
In
water; N,N-dimethyl-formamide;
DOI:10.1021/jm200629m
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C
2: bromine; sodium acetate; acetic acid / 0.33 h / 100 °C
With
bromine; sodium acetate; potassium carbonate; acetic acid;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm200629m
