2-Methoxyethyl phenyl ether

Base Information

• Chemical Name: 2-Methoxyethyl phenyl ether
• CAS No.: 41532-81-4
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Hs Code.: 2909309090
• European Community (EC) Number: 255-428-2
• NSC Number: 71175
• DSSTox Substance ID: DTXSID90194402
• Nikkaji Number: J100.041A
• Wikidata: Q83067156
• Mol file: 41532-81-4.mol

Synonyms:(2-Methoxyethoxy)benzene;2-Methoxyethyl phenyl ether;41532-81-4;Benzene, (2-methoxyethoxy)-;2-methoxyethoxybenzene;1-Methoxy-2-phenoxyethane;EINECS 255-428-2;AI3-08655;NSC71175;(2-methoxy)ethoxybenzene;(2-methoxy-ethoxy)-benzene;(2-Methoxyethoxy)benzene #;NCIOpen2_000450;SCHEMBL213738;SCHEMBL7104886;DTXSID90194402;NSC 71175;NSC-71175;AKOS009154070;CS-0217619;EN300-79779;35138-81-9

Chemical Property of 2-Methoxyethyl phenyl ether

Chemical Property:

• Vapor Pressure: 0.189mmHg at 25°C
• Boiling Point: 218.1°Cat760mmHg
• Flash Point: 79.1°C
• PSA: 18.46000
• Density: 0.995g/cm³
• LogP: 1.71180
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 87.6

Purity/Quality:

98% ^*data from raw suppliers

(2-methoxyethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOC1=CC=CC=C1

Technology Process of 2-Methoxyethyl phenyl ether

There total 14 articles about 2-Methoxyethyl phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + triphenylbismuth(V) diacetate (28899-97-0,7239-60-3) → 2-methoxyethyl phenyl ether (41532-81-4)

Guidance literature:

DOI:10.1039/c39860000065

Reference yield: 61.0%

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + methyl iodide (74-88-4) → 2-methoxyethyl phenyl ether (41532-81-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1039/c0ob00038h

Reference yield: 53.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-methoxyethyl phenyl ether (41532-81-4)

Guidance literature:

With lithium perchlorate; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; for 48h; chemoselective reaction; Irradiation; Inert atmosphere; Electrolysis;

DOI:10.1002/anie.202100222

upstream raw materials:

2-methoxy-ethyl p-toluenesulfonyloxy ester

phenol

sodium methylate

2-chloroethoxybenzene

Downstream raw materials:

1-(chloromethyl)-4-(2-methoxyethoxy)benzene

2-bromoacetic acid 2-phenoxyethyl ester

tert-butyl [2-(2-methoxyethoxy)phenyl](oxo)acetate

bis(2-(2-methoxyethoxy)phenyl) diselenide

Refernces

• 1、 St John-Campbell, Sahra,Ou, Alex K.,Bull, James A.. "Palladium-Catalyzed C(sp3)?H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group". supporting information. p. 17838 - 17843. Retrieved 2018/11/23.
• 2、 Eom, Min Sik,Noh, Jieun,Kim, Han-Sung,Yoo, Soyeon,Han, Min Su,Lee, Sunwoo. "High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for Halide Ions". supporting information. p. 1720 - 1723. Retrieved 2016/05/19.