2-Ethoxyethyl chloroformate

Base Information

• Chemical Name: 2-Ethoxyethyl chloroformate
• CAS No.: 628-64-8
• Molecular Formula: C5H9ClO3
• Molecular Weight: 152.578
• European Community (EC) Number: 211-048-9
• DSSTox Substance ID: DTXSID10211887
• Nikkaji Number: J205.900B
• Wikidata: Q72471573
• Mol file: 628-64-8.mol

Synonyms:2-Ethoxyethyl chloroformate;628-64-8;2-ethoxyethyl carbonochloridate;EINECS 211-048-9;2-ethoxyethyl chlorocarbonate;chlorocarbonic acid 2-ethoxy-ethyl ester;SCHEMBL616408;DTXSID10211887;AKOS006273195;Chlorocarbonic acid 2-ethoxyethyl ester;FT-0653672;EN300-6488980

Chemical Property of 2-Ethoxyethyl chloroformate

Chemical Property:

• Vapor Pressure: 1.96mmHg at 25°C
• Refractive Index: 1.421
• Boiling Point: 164.5 °C at 760 mmHg
• Flash Point: 61.2 °C
• PSA: 35.53000
• Density: 1.153 g/cm³
• LogP: 1.39830
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 152.0240218
• Heavy Atom Count: 9
• Complexity: 84.3

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxyethylchloroformate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCCOC(=O)Cl

Technology Process of 2-Ethoxyethyl chloroformate

There total 3 articles about 2-Ethoxyethyl chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-ethanol (110-80-5) + bis(trichloromethyl) carbonate (32315-10-9) → 2-ethoxyethyl chlorocarbonate (628-64-8)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

2-ethoxy-ethanol (110-80-5) + phosgene (75-44-5) → 2-ethoxyethyl chlorocarbonate (628-64-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; Rate constant; Mechanism; var. conc., without HCl;

Reference yield:

→ 2-ethoxyethyl chlorocarbonate (628-64-8)

Guidance literature:

/BRN= 1749802/;

DOI:10.1021/ja01279a029

upstream raw materials:

2-ethoxy-ethanol

phosgene

bis(trichloromethyl) carbonate

Downstream raw materials:

(4-hydroxy-phenyl)-carbamic acid-(2-ethoxy-ethyl ester)

di-(2-ethoxyethyl)peroxydicarbonate

(4-Oxiranylmethoxy-phenyl)-carbamic acid 2-ethoxy-ethyl ester

[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-carbamic acid 2-ethoxy-ethyl ester

Refernces

• 1、 -. "DRUG COMPOSITION HAVING ACTIVE INGREDIENT ADHERED AT HIGH CONCENTRATION TO SPHERICAL CORE". Page/Page column 56. . Retrieved 2010/02/14.
• 2、 -. "PRODRUGS OF IMIDAZOLE DERIVATIVES, FOR USE AS PROTON PUMP INHIBITORS IN THE TREATMENT OF E.G. PEPTIC ULCERS". Page 97-98. . Retrieved 2008/06/13.