Phenol, 3,5-diMethyl-, 1-acetate

Base Information

• Chemical Name: Phenol, 3,5-diMethyl-, 1-acetate
• CAS No.: 877-82-7
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Mol file: 877-82-7.mol

Synonyms:

Chemical Property of Phenol, 3,5-diMethyl-, 1-acetate

Chemical Property:

• Refractive Index: 1.5070 (estimate)
• Boiling Point: 237°C (estimate)
• Density: 1.0624

Purity/Quality:

98%,99%, ^*data from raw suppliers

ACETIC ACID 3,5-DIMETHYL-PHENYL ESTER AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 3,5-diMethyl-, 1-acetate

There total 11 articles about Phenol, 3,5-diMethyl-, 1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 5-acetoxy-m-xylene (877-82-7)

Guidance literature:

With SBA-15-Ph-Pr-SO₃H; at 20 ℃; for 0.166667h;

DOI:10.1139/v2012-018

Reference yield: 91.7%

3,5-dimethylacetophenone (5379-16-8) → 5-acetoxy-m-xylene (877-82-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Solvent; Reflux;

Reference yield: 90.0%

acetyl chloride (75-36-5) + 3,5-Dimethylphenol (108-68-9,50356-23-5) → 5-acetoxy-m-xylene (877-82-7)

Guidance literature:

With Fe/SWCNTs; at 20 ℃; for 0.2h;

DOI:10.1002/adsc.201000365

upstream raw materials:

acetic anhydride

3,5-Dimethylphenol

acetic acid

3,5-dimethyl-2,4-hexadienoic acid

Downstream raw materials:

acetic acid 3,5-bis(bromomethyl)phenyl ester

1-(2-hydroxy-4,6-dimethylphenyl)ethanone

3,5-Dimethylphenol

3-(3-Methoxy-5-methyl-phenyl)-propanol-⁽¹⁾

Refernces

• 1、 Bonrath, Werner,Létinois, Ulla,Lin, Ronghe,Medlock, Jonathan,Mitchell, Sharon,Netscher, Thomas,Pérez-Ramírez, Javier,Stemmler, René T.. "Substrate substitution effects in the Fries rearrangement of aryl esters over zeolite catalysts". . p. 4282 - 4292. Retrieved 2020/07/30.
• 2、 Zhang, Jieyu,Ke, Qiumin,Tian, Feitao,Jiang, Bei,Ji, Chang-An,Zhang, Lingling,Yu, Jian,Huang, Dayun,Yan, Guobing. "Copper-Catalyzed Acetylation of Electron-Rich Phenols and Anilines". supporting information. p. 726 - 730. Retrieved 2019/03/26.