2,4-DICHLORO-OMEGA-NITROSTYRENE

Base Information

• Chemical Name: 2,4-DICHLORO-OMEGA-NITROSTYRENE
• CAS No.: 34209-97-7
• Molecular Formula: C₈H₅Cl₂NO₂
• Molecular Weight: 218.039
• Mol file: 34209-97-7.mol

Synonyms:Benzene,2,4-dichloro-1-(2-nitroethenyl)-, (E)-; Styrene, 2,4-dichloro-b-nitro-, (E)- (8CI);1,3-Dichloro-4-((E)-2-nitroethenyl)benzene; 2,4-Dichloro-trans-b-nitrostyrene

Chemical Property of 2,4-DICHLORO-OMEGA-NITROSTYRENE

Chemical Property:

• Melting Point: 115-119 °C(lit.)
• Boiling Point: 334.1°Cat760mmHg
• Flash Point: 155.9°C
• PSA: 45.82000
• Density: 1.447g/cm³
• LogP: 3.76400

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-36-50/53
• Safety Statements: 26-36-60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLORO-OMEGA-NITROSTYRENE

There total 7 articles about 2,4-DICHLORO-OMEGA-NITROSTYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

nitromethane (75-52-5) + 2,4-dichlorobenzaldeyhde (874-42-0) → 2,4-dichloro-1-(2-nitrovinyl)benzene (34209-97-7,18984-21-9)

Guidance literature:

With aluminum oxide; potassium carbonate; for 0.0666667h; microwave irradiation;

DOI:10.1081/SCC-120014781

Reference yield: 87.0%

nitromethane (75-52-5) + 2,4-dichlorobenzaldeyhde (874-42-0) → trans-2,4-dichloro-β-nitrostyrene (18984-21-9,34209-97-7)

Guidance literature:

With ethylenediamine; for 10h; Reflux;

DOI:10.1002/cjoc.201201094

Reference yield: 87.0%

C11H7Cl2N3O2 → trans-2,4-dichloro-β-nitrostyrene (18984-21-9,34209-97-7)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; In toluene; at 45 - 50 ℃;

DOI:10.1039/c6ra06644e

upstream raw materials:

nitromethane

2,4-dichlorobenzaldeyhde

2-(2,4-dichlorobenzylidene)malononitrile

Downstream raw materials:

6-Nitro-5-<2,4-dichlorphenyl>-bicyclo<2.2.1>hepten-(2)

(R)-3-(1-(2,4-dichlorophenyl)-2-nitroethyl)pentane-2,4-dione

2-(2,4-dichlorophenyl)-1-nitro-3-phenylpropane

2,4-dichloro-1-((2R,3R)-1,3-dinitrobutan-2-yl)lbenzene

Refernces

• 1、 -. "Synthesis method of lifitegrast intermediate 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline". Paragraph 0066-0069. . Retrieved 2020/05/05.
• 2、 Byrne, Andrew J.,Bright, Sandra A.,Fayne, Darren,McKeown, James P.,McCabe, Thomas,Twamley, Brendan,Williams, Clive,Meegan, Mary J.. "Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma". . p. 181 - 199. Retrieved 2018/03/13.