Pyridin-4-ylmethanamine hydrochloride

Base Information

• Chemical Name: Pyridin-4-ylmethanamine hydrochloride
• CAS No.: 64460-41-9
• Molecular Formula: C6H8N2^.HCl
• Molecular Weight: 144.604
• Hs Code.: 2933399090
• UNII: JF7M9XZ7Z2
• DSSTox Substance ID: DTXSID90481889
• NSC Number: 194303
• Mol file: 64460-41-9.mol

Synonyms:PYRIDIN-4-YLMETHANAMINE HYDROCHLORIDE;64460-41-9;PYRIDIN-4-YLMETHANAMINE HCL;pyridin-4-ylmethanamine;hydrochloride;4-(Aminomethyl)pyridine Hydrochloride;(pyridin-4-yl)methanamine hydrochloride;4-Pyridinemethanamine, monohydrochloride;C-Pyridin-4-yl-methylamine hydrochloride;JF7M9XZ7Z2;SCHEMBL2674696;DTXSID90481889;MFCD06637470;NSC194303;AKOS015891850;CS-W005997;DS-2533;NSC-194303;SB53040;AC-27372;AM101076;4-Pyridinemethanamine, hydrochloride (1:1);FT-0702507

Chemical Property of Pyridin-4-ylmethanamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0674mmHg at 25°C
• Melting Point: 207-208 °C
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 108.3 °C
• PSA: 38.91000
• LogP: 2.04260
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 144.0454260
• Heavy Atom Count: 9
• Complexity: 57.5

Purity/Quality:

99% ^*data from raw suppliers

pyridin-4-ylmethanamineHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1CN.Cl

Technology Process of Pyridin-4-ylmethanamine hydrochloride

There total 5 articles about Pyridin-4-ylmethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

pyridine-4-carbaldehyde (872-85-5) → C-Pyridin-4-yl-methylamine; hydrochloride (18205-56-6,64460-41-9)

Guidance literature:

pyridine-4-carbaldehyde; With pyridoxal 5'-phosphate; ω-transaminase from Bacillus megaterium; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

Reference yield:

isonicotinamide (1453-82-3) → pyridine-4-carbonitrile (100-48-1) + pyridin-4-ylmethanamine hydrochloride (64460-41-9)

Guidance literature:

isonicotinamide; With phenylsilane; C₃₆H₄₈F₆N₆NiO₅S₂; In toluene; at 110 ℃; for 12h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In diethyl ether; Overall yield = 23 percent; Overall yield = 94 percentChromat.;

DOI:10.1039/d1cc03537a

Reference yield:

4-(1-acetyl-4(1H)-pyridylidene)-2-methyl-2-oxazolin-5-one (85127-48-6) → C-Pyridin-4-yl-methylamine; hydrochloride (18205-56-6,64460-41-9) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With hydrogenchloride; In water; for 3h; Yield given; Heating;

upstream raw materials:

4-(1-acetyl-4(1H)-pyridylidene)-2-methyl-2-oxazolin-5-one

pyridine

pyridine-4-carbaldehyde

4-picolylchloride hydrochloride

Downstream raw materials:

4-(4-methoxyphenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine

4-(4-chlorophenyl)-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine

3-(pyridine-4-ylmethyl)-4-p-tolylthiazol-2(3H)imine

4-phenyl-3-(pyridine-4-ylmethyl)thiazol-2(3H)imine

Refernces

• 1、 Bera, Jitendra K.,Pandey, Pragati. "Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex". supporting information. p. 9204 - 9207. Retrieved 2021/09/20.
• 2、 Hirota, Kazuhiro,Shimamura, Michiya,Ikeda, Mikiko,Ohmori, Shinji. "A Facile Preparation of 4-(1-acetyl-4(1H)-pyridylidene)-2-oxazolin-5-ones". . p. 1551 - 1552. Retrieved 2007/10/02.