Ethyl 5-broMo-2-furoate, 97+%

Base Information

• Chemical Name: Ethyl 5-broMo-2-furoate, 97+%
• CAS No.: 6132-37-2
• Molecular Formula: C7H7BrO3
• Molecular Weight: 219.035
• Hs Code.: 2932190090
• Mol file: 6132-37-2.mol

Synonyms:2-bromo-5-ethoxycarbonyl-furan;ethyl 5-bromo-2-furancarboxylate;2-bromo-5-(carbethoxy)furan;5-bromo-furan-2-carboxylic acid ethyl ester;ETHYL 5-BROMO-2-FUROATE;

Chemical Property of Ethyl 5-broMo-2-furoate, 97+%

Chemical Property:

• Vapor Pressure: 0.0325mmHg at 25°C
• Melting Point: 17 °C
• Refractive Index: 1.52
• Boiling Point: 243.2°Cat760mmHg
• Flash Point: 100.9°C
• PSA: 39.44000
• Density: 1.533g/cm³
• LogP: 2.21880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl5-bromofuran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-broMo-2-furoate, 97+%

There total 13 articles about Ethyl 5-broMo-2-furoate, 97+% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

5-bromofuran-2-carbonyl chloride (26726-16-9) + ethanol (64-17-5) → ethyl 5-bromofuran-2-carboxylate (6132-37-2)

Guidance literature:

With triethylamine;

DOI:10.1021/jo00244a048

Reference yield: 93.0%

5-bromo-furan-2-carboxylic acid (585-70-6) + ethanol (64-17-5) → ethyl 5-bromofuran-2-carboxylate (6132-37-2)

Guidance literature:

5-bromo-furan-2-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

ethanol; With triethylamine; In dichloromethane; for 15h;

Reference yield: 93.0%

5-methylfuran-2-carboxylic acid (1917-15-3) + ethanol (64-17-5) → ethyl 5-bromofuran-2-carboxylate (6132-37-2)

Guidance literature:

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 15h;

upstream raw materials:

5-bromo-furan-2-carboxylic acid

ethanol

5-bromofuran-2-carbonyl chloride

ethyl iodide

Downstream raw materials:

5-[2-methyl-5-(4-morpholin-4-yl-phenylcarbamoyl)-phenyl]-furan-2-carboxylic acid [4-(1.1-dioxo-1lambda-*6*-thiomorpholin-4-ylmethyl)-phenyl]-amide

5-[2-methyl-5-(4-morpholin-4-yl-phenylcarbamoyl)-phenyl]-furan-2-carboxylic acid

5-(4-chloro-3-fluorophenyl)furan-2-carboxylic acid

5-pyridin-2-ylfuran-2-carboxylic acid ethyl ester

Refernces

• 1、 Jiang, Huanfeng,Luo, Jiajun,Xie, Yi,Yin, Biaolin,Yu, Bin. "Synthesis of [2,2’]Bifuranyl-5,5’-dicarboxylic Acid Esters via Reductive Homocoupling of 5-Bromofuran-2-carboxylates Using Alcohols as Reductants?". . p. 62 - 68. Retrieved 2020/12/09.
• 2、 -. "Preparation method of ethyl 5-bromo-2-furoate". Paragraph 0011. . Retrieved 2017/07/05.