Ethanethioamide, N-(3-methoxyphenyl)-

Base Information

• Chemical Name: Ethanethioamide, N-(3-methoxyphenyl)-
• CAS No.: 87956-83-0
• Molecular Formula: C9H11NOS
• Molecular Weight: 181.258
• Mol file: 87956-83-0.mol

Synonyms:Thioessigsaeure-m-anisidid;m-methoxythioacetanilide;3-Methoxy-thioacetanilid;thioacetic acid m-anisidide;

Chemical Property of Ethanethioamide, N-(3-methoxyphenyl)-

Chemical Property:

• PSA: 60.39000
• LogP: 2.67490

Purity/Quality:

N-(3-Methoxyphenyl)ethanethioamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanethioamide, N-(3-methoxyphenyl)-

There total 4 articles about Ethanethioamide, N-(3-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(3-methoxy-phenyl)-ethanone oxime (122806-25-1) → N-(3-methoxyphenyl)ethanethioamide (87956-83-0)

Guidance literature:

1-(3-methoxy-phenyl)-ethanone oxime; With triethylamine; p-toluenesulfonyl chloride; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

With thiourea; In acetonitrile; for 2h; Reflux; Inert atmosphere;

DOI:10.1055/s-0030-1259720

Reference yield:

m-methoxyacetanilide (588-16-9) → N-(3-methoxyphenyl)ethanethioamide (87956-83-0)

Guidance literature:

With phosphorous (V) sulfide; benzene;

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → N-(3-methoxyphenyl)ethanethioamide (87956-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: Lawessons reagent / chlorobenzene / 3 h / 135 °C

With Lawessons reagent; pyridine; In chlorobenzene;

upstream raw materials:

m-methoxyacetanilide

1-(3-methoxy-phenyl)-ethanone oxime

m-Anisidine

Downstream raw materials:

2-methylbenzothiazol-7-ol

2-methyl-5-benzothiazolol

5-methoxy-2-methylbenzo[d]thiazole

7-methoxy-2-methyl-benzothiazole

Refernces

• 1、 Liu, Li-Feng,An, Na,Pi, Hong-Jun,Ying, Jun,Du, Wenting,Deng, Wei-Ping. "Facile and odorless one-pot process for the synthesis of N-substituted thioamides via TsCl-mediated Beckmann rearrangement of ketoximes". supporting information; experimental part. p. 979 - 981. Retrieved 2011/06/11.