Methoxyimino-acetic acid

Base Information

• Chemical Name: Methoxyimino-acetic acid
• CAS No.: 88012-58-2
• Molecular Formula: C3H5NO3
• Molecular Weight: 103.078
• European Community (EC) Number: 843-288-0
• Mol file: 88012-58-2.mol

Synonyms:Methoxyimino-acetic acid;2-(methoxyimino)acetic acid;175030-38-3;88012-58-2;(2E)-2-methoxyiminoacetic Acid;(E)-2-(Methoxyimino)acetic acid;methoxyiminoacetic acid;SCHEMBL2698499;MFCD12910513;AKOS006374503;CS-0232698;EN300-128172

Chemical Property of Methoxyimino-acetic acid

Chemical Property:

• Boiling Point: 187.8±23.0 °C(Predicted)
• PSA: 58.89000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: -0.29680
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 103.026943022
• Heavy Atom Count: 7
• Complexity: 88.2

Purity/Quality:

99% ^*data from raw suppliers

2-(methoxyimino)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON=CC(=O)O
• Isomeric SMILES: CO/N=C/C(=O)O

Technology Process of Methoxyimino-acetic acid

There total 1 articles about Methoxyimino-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-methoxylamine hydrochloride (593-56-6) + Glyoxilic acid (298-12-4) → 2-[(methyloxy)imino]acetic acid (88012-58-2)

Guidance literature:

With pyridine; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ja064686s

Reference yield: 85.0%

2-[(methyloxy)imino]acetic acid (88012-58-2) + methyl (2S)-2-amino-3-{4'-[(tert-butyldimethylsilyl)oxy]phenyl}propanoate (216974-09-3) → (S,E)-methyl 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-2-(2-(methoxyimino)propanamido) propanoate

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.6b03548

Reference yield: 80.0%

2-[(methyloxy)imino]acetic acid (88012-58-2) + benzyl bromide (100-39-0) → (methoxyimino)acetic acid benzyl ester

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 17h;

DOI:10.1021/ja064686s

upstream raw materials:

N-methoxylamine hydrochloride

Glyoxilic acid

Downstream raw materials:

5-methoximinoacetyl-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-pyrazole

Refernces

• 1、 -. "COLCHICINE NEOGLYCOSIDES AND METHODS FOR THEIR SYNTHESIS AND USE". Page/Page column 28. . Retrieved 2008/12/06.