7-Chloro-4-(4-hydroxyanilino)quinoline

Base Information

• Chemical Name: 7-Chloro-4-(4-hydroxyanilino)quinoline
• CAS No.: 81099-86-7
• Molecular Formula: C15H11ClN2O
• Molecular Weight: 270.718
• Hs Code.: 2933499090
• Mol file: 81099-86-7.mol

Synonyms:4-(7-chloro-4-quinolinylamino)phenol;4-(7-Chlor-[4]chinolylamino)-phenol;7-Chlor-4-(4-hydroxy-anilino)-chinolin;GNF-PF-1310;4-(7-chloro-[4]quinolylamino)-phenol;4-(4'-hydroxyphenyl)amino-7-chloroquinoline;

Chemical Property of 7-Chloro-4-(4-hydroxyanilino)quinoline

Chemical Property:

• Vapor Pressure: 2.54E-08mmHg at 25°C
• Boiling Point: 439.1°Cat760mmHg
• Flash Point: 219.4°C
• PSA: 45.15000
• Density: 1.401g/cm³
• LogP: 4.41040

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-Chloro-4-(4-hydroxyanilino)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Amodiaquine (A634200) with antimalarial activity.

Technology Process of 7-Chloro-4-(4-hydroxyanilino)quinoline

There total 13 articles about 7-Chloro-4-(4-hydroxyanilino)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + 4-amino-phenol (123-30-8) → 4-[(7-chloroquinolin-4-yl)amino]phenol (81099-86-7)

Guidance literature:

With hydrogenchloride; potassium iodide; In ethanol; water; for 14h; Reflux;

DOI:10.1021/acs.jmedchem.0c01779

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + 4-amino-phenol; sulfate (3648-96-2,54646-39-8,63084-98-0) → 4-[(7-chloroquinolin-4-yl)amino]phenol (81099-86-7)

Guidance literature:

With water;

DOI:10.1021/ja01184a023

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + p-aminophenol hydrochloride (51-78-5) → 4-[(7-chloroquinolin-4-yl)amino]phenol (81099-86-7)

Guidance literature:

With water;

DOI:10.1021/ja01184a023

upstream raw materials:

7-chloro-1,2,3,4-tetrahydroquinolin-4-one

4-nitro-phenol

4-amino-phenol

4,7-dichloroquinoline

Downstream raw materials:

4-(7-chloro-quinolin-4-ylamino)-2-dibutylaminomethyl-phenol

4-(7'-chloroquinolin-4'-ylamino)-2,6-bis(diethylaminomethyl)phenol

4-[(7-chloroquinolin-4-yl)amino]-2,6-bis(4-methylpiperazin-1-ylmethyl)phenol

4-<3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyanilino>-7-chloroquinoline

Refernces

• 1、 -. "7-CHLORO-QUINOLIN-4-AMINE COMPOUNDS AND USES THEREOF FOR THE PREVENTION OR TREATMENT OF DISEASES INVOLVING FORMATION OF AMYLOID PLAQUES AND/OR WHERE A DYSFUNCTION OF THE APP METABOLISM OCCURS". Page/Page column 37. . Retrieved 2011/07/07.
• 2、 Motiwala, Hashim F.,Kumar, Raj,Chakraborti, Asit K.. "Microwave-accelerated solvent- and catalyst-free synthesis of 4-aminoaryl/alkyl-7-chloroquinolines and 2-aminoaryl/alkylbenzothiazoles". . p. 369 - 374. Retrieved 2008/02/11.