N-benzyloxycarbonyl-prolyl-alanine methyl ester

Base Information

• Chemical Name: N-benzyloxycarbonyl-prolyl-alanine methyl ester
• CAS No.: 135820-81-4
• Molecular Formula: C17H22 N2 O5
• Molecular Weight: 334.372
• Mol file: 135820-81-4.mol

Synonyms:N-(Benzyloxycarbonyl)-L-prolyl-D-alaninemethyl ester

Chemical Property of N-benzyloxycarbonyl-prolyl-alanine methyl ester

Chemical Property:

• Vapor Pressure: 1.27E-10mmHg at 25°C
• Boiling Point: 512.6°Cat760mmHg
• PKA: 13.69±0.20(Predicted)
• Flash Point: 263.8°C
• PSA: 88.43000
• Density: 1.231g/cm³
• LogP: 2.24350

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyloxycarbonyl-prolyl-alanine methyl ester

There total 1 articles about N-benzyloxycarbonyl-prolyl-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-alanine methyl ester hydrochloride (14316-06-4) + N-Benzyloxycarbonyl-L-proline (1148-11-4) → (S)-2-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester (135820-81-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2018.12.049

Reference yield: 88.0%

(S)-2-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester (135820-81-4) → (1'S)-2--3-aza-4-methyl-5-methoxy-1-oxacyclopenta-2,4-diene (134261-44-2)

Guidance literature:

With pyridine; trichlorophosphate; at 60 - 65 ℃; for 18h;

DOI:10.1021/ja00014a033

Reference yield:

(S)-2-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester (135820-81-4) → C16H20N2O5

Guidance literature:

(S)-2-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester; With potassium hydroxide; In methanol; water; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; pH=3;

DOI:10.1016/j.tetlet.2018.12.049

upstream raw materials:

D-alanine methyl ester hydrochloride

N-Benzyloxycarbonyl-L-proline

Downstream raw materials:

(1'S)-2--3-aza-4-methyl-5-methoxy-1-oxacyclopenta-2,4-diene

Refernces