4-Carboxylbenzocyclobutene

Base Information

• Chemical Name: 4-Carboxylbenzocyclobutene
• CAS No.: 875-94-5
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.161
• Hs Code.: 2916209090
• Mol file: 875-94-5.mol

Synonyms:4-Carboxyl benzocyclobutene;Bicyclo[4.2.0]octa-1,3,5-triene-3-carboxylic acid (7CI,8CI,9CI);4-CBCB

Chemical Property of 4-Carboxylbenzocyclobutene

Chemical Property:

• Appearance/Colour: White crystal
• Vapor Pressure: 0.000344mmHg at 25°C
• Melting Point: 139-140 °C
• Boiling Point: 306.1°C at 760 mmHg
• PKA: 4.44±0.20(Predicted)
• Flash Point: 137.5°C
• PSA: 37.30000
• Density: 1.307g/cm³
• LogP: 1.86860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Bicyclo[4.2.0]octa-1,3,5,7-tetraene-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Carboxylbenzocyclobutene

There total 4 articles about 4-Carboxylbenzocyclobutene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzocyclobutene (694-87-1) → 4-carboxybenzocyclobutene (875-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₄ / nitromethane

2: Br₂, aq. NaOH

With sodium hydroxide; bromine; tin(IV) chloride; In nitromethane;

DOI:10.1016/S0040-4020(01)97603-3

Reference yield:

4-Chloracetyl-1,2-dihydro-benzocyclobuten (19369-50-7) → 4-carboxybenzocyclobutene (875-94-5)

Guidance literature:

With sodium hypochlorite; In 1,4-dioxane;

Reference yield:

1-(bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl)ethan-1-one (875-93-4) → 4-carboxybenzocyclobutene (875-94-5)

Guidance literature:

With sodium hydroxide; bromine;

DOI:10.1016/S0040-4020(01)97603-3

upstream raw materials:

carbon dioxide

4-bromobenzocyclobutene

1-(bicyclo[4.2.0]octa-1⁽⁶⁾,2,4-trien-3-yl)ethan-1-one

4-Chloracetyl-1,2-dihydro-benzocyclobuten

Downstream raw materials:

bicyclo[4.2.0]octa-1,3,5-trien-4-amine

4-Carbamoyl-benzocyclobuten