Methyl 1-formylcyclopropane-1-carboxylate

Base Information

• Chemical Name: Methyl 1-formylcyclopropane-1-carboxylate
• CAS No.: 88157-41-9
• Molecular Formula: C6H8O3
• Molecular Weight: 128.128
• European Community (EC) Number: 816-230-7
• DSSTox Substance ID: DTXSID60697091
• Nikkaji Number: J1.301.674G
• Wikidata: Q82626912
• Mol file: 88157-41-9.mol

Synonyms:methyl 1-formylcyclopropane-1-carboxylate;88157-41-9;methyl 1-formylcyclopropanecarboxylate;Cyclopropanecarboxylic acid, 1-formyl-, methyl ester;SCHEMBL2547049;DTXSID60697091;RMPZPDNSMGBBAE-UHFFFAOYSA-N;MFCD15526934;AKOS023556431;PB43685;methyl1-formylcyclopropane-1-carboxylate;AS-43700;CS-0090863;M3045;EN300-85326;1-Formylcyclopropanecarboxylic acid methyl ester;1-FORMYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER;Z1255397310

Chemical Property of Methyl 1-formylcyclopropane-1-carboxylate

Chemical Property:

• Boiling Point: 161.6±23.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.336±0.06 g/cm3(Predicted)
• LogP: 0.13850
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 128.047344113
• Heavy Atom Count: 9
• Complexity: 146

Purity/Quality:

99% ^*data from raw suppliers

Methyl1-formylcyclopropanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1(CC1)C=O
• Uses: Methyl 1-formylcyclopropane-1-carboxylate, is a building block used in the synthesis of chemical compounds.

Technology Process of Methyl 1-formylcyclopropane-1-carboxylate

There total 6 articles about Methyl 1-formylcyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-formylcyclopropanecarboxylic acid (88157-18-0) → methyl 1-formylcyclopropane-1-carboxylate (88157-41-9)

Guidance literature:

at 0 ℃;

DOI:10.1021/jo00174a061

Reference yield: 99.0%

methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate (88157-42-0) → methyl 1-formylcyclopropane-1-carboxylate (88157-41-9)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at -5 - 20 ℃; for 0.416667h; Inert atmosphere;

Reference yield:

dimethyl 1,1-cyclopropanedicarboxylate (6914-71-2,151444-20-1) → methyl 1-formylcyclopropane-1-carboxylate (88157-41-9)

Guidance literature:

dimethyl 1,1-cyclopropanedicarboxylate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 7h;

With hydrogenchloride; ammonium chloride; In dichloromethane; water; at -78 - 20 ℃;

upstream raw materials:

diazomethane

1-formylcyclopropanecarboxylic acid

1-cyano-cyclopropanecarboxylic acid

dimethyl 1,1-cyclopropanedicarboxylate

Downstream raw materials:

methyl 1-(2,2-diphenylvinyl)cyclopropane-carboxylate

1-(bromomethyl)cyclopropanecarboxylate methyl ester

tert-butyl((1-(2,2-dibromovinyl)cyclopropyl)methoxy)diphenylsilane

tert-Butyl-[((Z)-1-hept-1-enyl)-cyclopropylmethoxy]-diphenyl-silane

Refernces

• 1、 -. "SUBSTITUTED TRICYCLICS AND METHOD OF USE". . . Retrieved 2017/02/09.
• 2、 -. "OXAZOLO [5, 4 -B] PYRIDIN- 5 -YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER". . . Retrieved 2012/06/16.