(R)-(-)-10-METHYL-1(9)-OCTAL-2-ONE

Base Information

• Chemical Name: (R)-(-)-10-METHYL-1(9)-OCTAL-2-ONE
• CAS No.: 63975-59-7
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.247
• Hs Code.: 2914299000
• Mol file: 63975-59-7.mol

Synonyms:2(3H)-Naphthalenone,4,4a,5,6,7,8-hexahydro-4a-methyl-, (R)-; (-)-4,4a,5,6,7,8-Hexahydro-4a-methyl-2(3H)-naphthalenone;(R)-(-)-10-Methyl-1(9)octal-2-one

Chemical Property of (R)-(-)-10-METHYL-1(9)-OCTAL-2-ONE

Chemical Property:

• Vapor Pressure: 0.00396mmHg at 25°C
• Refractive Index: n20/D 1.525(lit.)
• Boiling Point: 155 °C17 mm Hg(lit.)
• Flash Point: >230 °F
• PSA: 17.07000
• Density: 1.018 g/mL at 20 °C(lit.)
• LogP: 2.85600
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(R)-(-)-4,4a,5,6,7,8-Hexahydro-4a-methyl-2(3H)- naphthalenone for synthesis. CAS 63975-59-7, molar mass 164.24 g/mol., for synthesis ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36-20/21/22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-10-METHYL-1(9)-OCTAL-2-ONE

There total 24 articles about (R)-(-)-10-METHYL-1(9)-OCTAL-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-(+)-2-methyl-2-(3-oxobutyl)cyclohexanone (91306-30-8) → (R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one (63975-59-7)

Guidance literature:

With methanol; sodium methylate; at 35 ℃; for 1h;

DOI:10.1021/ja00287a061

Reference yield: 55.0%

methyl vinyl ketone (78-94-4,25038-87-3) + 2-Methylcyclohexanone (583-60-8) → (R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one (63975-59-7)

Guidance literature:

With (S)-1-phenyl-ethylamine;

DOI:10.1021/ja953416z

Reference yield: 23.0%

4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one (826-56-2) → (+)-6-methylbicyclo<4.4.0>dec-1-en-3-one (826-56-2,4087-39-2,40573-28-2,63975-59-7)

Guidance literature:

DOI:10.1246/cl.1985.885

upstream raw materials:

2,4,6-trimethyl-pyridine

3t-Brom-4-ar-methyl(8atH)-decalon-(2)

(R)-(+)-2-methyl-2-(3-oxobutyl)cyclohexanone

8aα-hydroxy-4aα-methyloctahydronaphthalen-2(1H)-one

Downstream raw materials:

9-methyl-1,2,6,7,8,9-hexahydronaphthalene-3(5H)-one 2,4-dinitrophenylhydrazone

(R)-4,4a,5,6,7,8-hexahydro-3-[4'(2'-ketobutyl)]-4aβ-methyl-2(3H)-naphthalenone

Refernces

• 1、 Zhong,Hoffmann,Lerner,Danishefsky,Barbas III. "Antibody-catalyzed enantioselective Robinson annulation". . p. 8131 - 8132. Retrieved 2007/10/03.
• 2、 Tamogami, Shigeru,Katayama, Masato,Marumo, Shingo,Isobe, Minoru. "Synthesis of the 5-demethyl-6-deoxy analogue of sporogen AO-1, a sporogenic substance of Aspergillus oryzae". . p. 1372 - 1374. Retrieved 2007/10/03.