Technology Process of 1H-Pyrrole-3-methanol, 2-chloro-5-phenyl-1-(phenylsulfonyl)-
There total 4 articles about 1H-Pyrrole-3-methanol, 2-chloro-5-phenyl-1-(phenylsulfonyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 2-chloro-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -70 ℃;
for 1h;
With
hydrogenchloride; water;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
2.2: 24 h / 20 °C
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C
With
hydrogenchloride; sodium hydride; diisobutylaluminium hydride;
In
tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.04.014
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / 0.75 h / 40 °C
1.2: 18.5 h / 20 °C
2.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
3.2: 24 h / 20 °C
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C
With
hydrogenchloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate;
In
tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.04.014