1-(2-chloroethyl)-1-nitroso-3-phenylurea

Base Information

• Chemical Name: 1-(2-chloroethyl)-1-nitroso-3-phenylurea
• CAS No.: 13206-67-2
• Molecular Formula: C9H10ClN3O2
• Molecular Weight: 227.65
• Mol file: 13206-67-2.mol

Synonyms:

Chemical Property of 1-(2-chloroethyl)-1-nitroso-3-phenylurea

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.31g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-chloroethyl)-1-nitroso-3-phenylurea

There total 4 articles about 1-(2-chloroethyl)-1-nitroso-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

1-(2-chloroethyl)-3-phenylurea (7144-13-0) → 1-(2-chloroethyl)-3-phenyl-1-nitrosourea (13206-67-2) + C9H10ClN3O2

Guidance literature:

With formic acid; sodium nitrite; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.saa.2021.119579

Reference yield:

1,2,2,2-Tetrachloroethyl N-(2-chloroethyl) N-nitroso-carbamate (113900-20-2) + aniline (62-53-3) → 1-(2-chloroethyl)-3-phenyl-1-nitrosourea (13206-67-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 2h; Yield given; Ambient temperature;

DOI:10.1055/s-1987-28160

Reference yield:

phenyl isocyanate (103-71-9) → 1-(2-chloroethyl)-3-phenyl-1-nitrosourea (13206-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) CHCl₃, (ii) aq. HCl

2: aq. NaNO₂, HCO₂H

With formic acid; sodium nitrite;

DOI:10.1021/jm00342a010

upstream raw materials:

1,2,2,2-Tetrachloroethyl N-(2-chloroethyl) N-nitroso-carbamate

aniline

phenyl isocyanate

1-(2-chloroethyl)-3-phenylurea

Refernces

• 1、 Barcelo, Gerard,Senet, Jean-Pierre,Sennyey, Gerard. "1,2,2,2-Tetrachloroethyl Carbamates: Versatile Intermediates for the Synthesis of N-Nitrosoureas". . p. 1027 - 1029. Retrieved 2007/10/02.