5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy-

Base Information

• Chemical Name: 5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy-
• CAS No.: 88258-42-8
• Molecular Formula: C10H8O5
• Molecular Weight: 208.16800
• ChEMBL ID: CHEMBL1241366
• DSSTox Substance ID: DTXSID60480662
• Wikidata: Q82315617
• Mol file: 88258-42-8.mol

Synonyms:88258-42-8;6-hydroxy-4-methoxybenzofuran-5-carboxylic acid;5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy-;6-hydroxy-4-methoxy-1-benzofuran-5-carboxylic acid;SCHEMBL9129946;CHEMBL1241366;DTXSID60480662;6-hydroxy-4-methoxy-benzofuran-5-carboxylic acid

Chemical Property of 5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy-

Chemical Property:

• Melting Point: 180 °C(Solv: ethanol (64-17-5))
• Boiling Point: 247.9±20.0 °C(Predicted)
• PSA: 79.90000
• Density: 1.473±0.06 g/cm3(Predicted)
• LogP: 1.84520
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 208.03717335
• Heavy Atom Count: 15
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC2=C1C=CO2)O)C(=O)O

Technology Process of 5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy-

There total 1 articles about 5-Benzofurancarboxylic acid, 6-hydroxy-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

visnagin (82-57-5) → 5-acetyl-4-methoxybenzofuran-6-ol (484-27-5) + 6-hydroxy-4-methoxybenzofuran-5-carboxylic acid (88258-42-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1002/hlca.19560390337

Reference yield: 100.0%

6-hydroxy-4-methoxybenzofuran-5-carboxylic acid (88258-42-8) + 2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → 6-hydroxy-4-methoxy-benzofuran-5-carboxylic acid (2,4-dimethoxy-phenyl)-amide (914485-68-0)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; for 3h; Heating;

DOI:10.1002/ardp.200600020

Reference yield: 95.0%

6-hydroxy-4-methoxybenzofuran-5-carboxylic acid (88258-42-8) + aniline (62-53-3) → 6-Hydroxy-4-methoxy-benzofuran-5-carboxylic acid phenylamide (88258-51-9)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; for 3h; Heating;

DOI:10.1002/ardp.200600020

upstream raw materials:

visnagin

Downstream raw materials:

6-Hydroxy-4-methoxy-7-(4-phenyl-piperidin-1-ylmethyl)-benzofuran-5-carboxylic acid

6-Hydroxy-4-methoxy-benzofuran-5-carboxylic acid phenylamide

6-hydroxy-4-methoxy-benzofuran-5-carboxylic acid (2,4-dimethoxy-phenyl)-amide

carbonic acid ethyl ester 4-methoxy-5-phenylcarbamoyl-benzofuran-6-yl ester