4-Fluoropyridine

Base Information

• Chemical Name: 4-Fluoropyridine
• CAS No.: 694-52-0
• Molecular Formula: C5H4 F N
• Molecular Weight: 97.0919
• Hs Code.: 2933399090
• Mol file: 694-52-0.mol

Synonyms:4-Fluoropyridine;p-Fluoropyridine

Chemical Property of 4-Fluoropyridine

Chemical Property:

• Vapor Pressure: 24mmHg at 25°C
• Refractive Index: 1.473
• Boiling Point: 114.1 ºC at 760 mmHg
• PKA: 4.15±0.10(Predicted)
• Flash Point: 22.8ºC
• PSA: 12.89000
• Density: 1.117 g/cm³
• LogP: 1.22070

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:Flammable.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi,Xn,F
• Statements: 11-22-37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoropyridine was useful for studying the interaction of pyridines with OCS.

Technology Process of 4-Fluoropyridine

There total 9 articles about 4-Fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridin-4-ol (626-64-2,157061-69-3) → 4-fluoropyridine (694-52-0)

Guidance literature:

With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride; diphenylzinc; In toluene; at 80 ℃; for 20h; Product distribution / selectivity; Sealed vial;

Reference yield: 95.0%

4-aminopyridine (504-24-5) → 4-fluoropyridine (694-52-0)

Guidance literature:

With pyridine hydrogenfluoride; sodium nitrite; 1.) O deg C, 20 min, 2.) 60 deg C, 1 h;

DOI:10.1016/0040-4020(95)00867-8

Reference yield: 89.0%

→ 4-fluoropyridine (694-52-0)

Guidance literature:

upstream raw materials:

4-aminopyridine

hydrogen fluoride

water

pyridine

Downstream raw materials:

1-(4'-pyridyl)-4-pyridone

1,1,1-tris[(pyridine-4-yloxy)methyl]ethane

4-(cyclohexyl(5-ethoxy-4-(pyridin-4-yl)oxazol-2-yl)methyl)morpholine

(E)-4-(1-(5-ethoxy-4-(pyridin-4-yl)oxazol-2-yl)-3-phenylallyl)morpholine

Refernces

• 1、 Fang, Bin,Tao, Haisheng,Kan, Xianwen,Shang, Yongjia. "Selective electrochemical synthesis of 4-fluoropyridine using ET 3N-3HF". . p. 305 - 306. Retrieved 2004.
• 2、 Ye, Yingda,Schimler, Sydonie D.,Hanley, Patrick S.,Sanford, Melanie S.. "Cu(OTf)2-mediated fluorination of aryltrifluoroborates with potassium fluoride". supporting information. p. 16292 - 16295. Retrieved 2013/12/04.
• 3、 Tang, Pingping,Wang, Weike,Ritter, Tobias. "Deoxyfluorination of phenols". supporting information; experimental part. p. 11482 - 11484. Retrieved 2011/10/02.