3,4-Dimethoxybenzamide

Base Information

• Chemical Name: 3,4-Dimethoxybenzamide
• CAS No.: 1521-41-1
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 2924299090
• European Community (EC) Number: 216-190-5
• NSC Number: 370837
• UNII: SEW9F1FKI8
• DSSTox Substance ID: DTXSID1074549
• Nikkaji Number: J206.732C
• Wikidata: Q72467613
• Metabolomics Workbench ID: 140235
• ChEMBL ID: CHEMBL505584
• Mol file: 1521-41-1.mol

Synonyms:3,4-Dimethoxybenzamide;1521-41-1;Veratramide;Benzamide, 3,4-dimethoxy-;Veratrimidic acid;3,4-Dimethoxy-benzamide;EINECS 216-190-5;SEW9F1FKI8;NSC 370837;BRN 2646714;MFCD00017128;NSC-370837;3-10-00-01427 (Beilstein Handbook Reference);NSC370837;UNII-SEW9F1FKI8;Oprea1_176663;Oprea1_802187;SCHEMBL335681;CHEMBL505584;DTXSID1074549;AMY28152;HY-N1777;AKOS000593686;SR-4191;AS-57779;LS-26547;SY275554;CS-0017631;FT-0656647;A809265;J-511211;Z33546772

Chemical Property of 3,4-Dimethoxybenzamide

Chemical Property:

• Vapor Pressure: 0.00428mmHg at 25°C
• Melting Point: 163-164℃
• Refractive Index: 1.534
• Boiling Point: 278.4 °C at 760 mmHg
• Flash Point: 126.1 °C
• PSA: 61.55000
• Density: 1.16 g/cm³
• LogP: 1.50300
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

99%, ^*data from raw suppliers

3,4-Dimethoxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)N)OC

Technology Process of 3,4-Dimethoxybenzamide

There total 29 articles about 3,4-Dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dimethoxy-benzaldehyde (120-14-9) → veratramide (1521-41-1)

Guidance literature:

With hydroxylamine hydrochloride; In acetonitrile; for 0.0652778h; Microwave irradiation;

DOI:10.5012/bkcs.2012.33.7.2129

Reference yield: 97.0%

3,4-dimethoxy-N-phenyl-N-tosylbenzamide → veratramide (1521-41-1)

Guidance literature:

With ammonium carbonate; In dimethyl sulfoxide; at 25 ℃; for 6h;

DOI:10.1021/acs.orglett.0c00958

Reference yield: 95.0%

veratronitrile (2024-83-1) → veratramide (1521-41-1)

Guidance literature:

With oxygen; copper diacetate; In acetic acid; at 120 ℃; for 10h;

DOI:10.1039/c3cc42683a

upstream raw materials:

1,2-dimethoxybenzene

carbamic chloride

veratronitrile

formamide

Downstream raw materials:

1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline

Veratric acid

3,4-dimethoxyaniline

5-(3,4-dimethoxy-phenyl)-[1,3,4]oxathiazol-2-one

Refernces

• 1、 Govindan, Karthick,Chen, Nian-Qi,Chuang, Yu-Wei,Lin, Wei-Yu. "Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups". supporting information. p. 9419 - 9424. Retrieved 2021/11/30.
• 2、 Thirumal, Muniyappan,Venkatachalam, Galmari,Venkattappan, Anbazhagan. "Ruthenium(III) 2-(aminofluoreneazo)phenolate complexes: Synthesis, characterization, catalytic activity in amidation reaction and Fluorescence quenching studies". . . Retrieved 2020/07/15.