4-Hydroxy-8-(hydroxy(oxido)amino)-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 4-Hydroxy-8-(hydroxy(oxido)amino)-3-quinolinecarboxylic acid
• CAS No.: 35973-25-2
• Molecular Formula: C10H6 N2 O5
• Molecular Weight: 234.16
• Hs Code.: 2933499090
• Mol file: 35973-25-2.mol

Synonyms:NSC 15765

Chemical Property of 4-Hydroxy-8-(hydroxy(oxido)amino)-3-quinolinecarboxylic acid

Chemical Property:

• Vapor Pressure: 2.04E-08mmHg at 25°C
• Boiling Point: 437.2°Cat760mmHg
• PKA: 0.35±0.30(Predicted)
• Flash Point: 218.2°C
• PSA: 116.24000
• Density: 1.624g/cm³
• LogP: 2.07000

Purity/Quality:

NLT 98% ^*data from raw suppliers

NSC15765 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-8-nitro-3-quinolinecarboxylic acid is used to identify enterobiome metabolites and putative uremic toxins as substrates of organic anion Transporter 1 (Oat1).

Technology Process of 4-Hydroxy-8-(hydroxy(oxido)amino)-3-quinolinecarboxylic acid

There total 4 articles about 4-Hydroxy-8-(hydroxy(oxido)amino)-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-nitro-4-hydroxy-quinoline-3-carboxylic acid ethylester (109799-69-1) → 4-hydroxy-8-nitroquinoline-3-carboxylic acid (35973-25-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01211a038

Reference yield:

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester (7255-58-5) → 4-hydroxy-8-nitroquinoline-3-carboxylic acid (35973-25-2)

Guidance literature:

Multi-step reaction with 2 steps

2: aqueous NaOH

With sodium hydroxide;

DOI:10.1021/ja01211a038

Reference yield:

2-nitro-aniline (88-74-4) → 4-hydroxy-8-nitroquinoline-3-carboxylic acid (35973-25-2)

Guidance literature:

Multi-step reaction with 3 steps

3: aqueous NaOH

With sodium hydroxide;

DOI:10.1021/ja01211a038

upstream raw materials:

8-nitro-4-hydroxy-quinoline-3-carboxylic acid ethylester

<<(2-nitropenyl)amino>methylene>propanedioic acid diethyl ester

2-nitro-aniline

Refernces

• 1、 -. "4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents". . . Retrieved 2008/06/13.