3-(Methoxymethyl)-2,4,6-trimethylbenzaldehyde

Base Information

• Chemical Name: 3-(Methoxymethyl)-2,4,6-trimethylbenzaldehyde
• CAS No.: 88339-51-9
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• DSSTox Substance ID: DTXSID60401892
• Wikidata: Q82205181
• Mol file: 88339-51-9.mol

Synonyms:3-(methoxymethyl)-2,4,6-trimethylbenzaldehyde;88339-51-9;Benzaldehyde, 3-(methoxymethyl)-2,4,6-trimethyl-;DTXSID60401892;2,4,6-trimethyl-3-(methoxymethyl)benzaldehyde;EN300-374407;Z1416158269

Chemical Property of 3-(Methoxymethyl)-2,4,6-trimethylbenzaldehyde

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 192.115029749
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1COC)C)C=O)C

Technology Process of 3-(Methoxymethyl)-2,4,6-trimethylbenzaldehyde

There total 2 articles about 3-(Methoxymethyl)-2,4,6-trimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 2,4,6-trimethyl-3-(chloromethyl)benzaldehyde (105041-52-9) → methoxymethylformylmesitylene (88339-51-9)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

DOI:10.1007/BF00961246

Reference yield:

2-chloromethyl-1,3,5-trimethylbenzene (1585-16-6) → methoxymethylformylmesitylene (88339-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / TiCl₄ / CH₂Cl₂ / 0.5 h / 20 °C

2: 88 percent / NaOH / 3 h / Heating

With sodium hydroxide; titanium tetrachloride; In dichloromethane;

DOI:10.1007/BF00961246

Reference yield:

methoxymethylformylmesitylene (88339-51-9) → C12H15NO2

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; hydroxylamine hydrochloride / ethanol; water / 4 h / Heating

2: sodium hydroxide; sodium hypochlorite / dichloromethane / 1 h / 5 - 15 °C

With sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; In ethanol; dichloromethane; water;

DOI:10.1007/BF00961380

upstream raw materials:

methanol

2,4,6-trimethyl-3-(chloromethyl)benzaldehyde

2-chloromethyl-1,3,5-trimethylbenzene

Downstream raw materials:

3-Methoxymethyl-2,4,6-trimethyl-benzaldehyde oxime

Refernces