GDP-L-Galactose

Base Information

• Chemical Name: GDP-L-Galactose
• CAS No.: 6815-91-4
• Molecular Formula: C16H25 N5 O16 P2
• Molecular Weight: 605.346
• Mol file: 6815-91-4.mol

Synonyms:Guanosine 5'-(trihydrogenpyrophosphate), mono-b-L-galactopyranosyl ester(8CI); Guanosine 5'-pyrophosphate, b-L-galactopyranosyl ester (6CI); GDP-Gal; GDP-L-galactose; GDP-galactose; GDP-b-L-galactose; Guanosine 5'-(trihydrogen diphosphate), P'-L-galactopyranosyl ester; Guanosine5'-(trihydrogen diphosphate),P'-L-galactosyl ester; Guanosine5'-diphosphate-L-galactose; Guanosine5'-pyrophosphate, L-galactosyl ester; Guanosine 5'-pyrophosphate, galactosylester; Guanosine 5'-pyrophosphate, b-L-galactosyl ester; Guanosine diphosphate galactose; Guanosine diphosphogalactose

Chemical Property of GDP-L-Galactose

Chemical Property:

• PKA: 1.10±0.50(Predicted)
• PSA: 351.34000
• Density: 2.51±0.1 g/cm3(Predicted)
• LogP: -4.04730

Purity/Quality:

98%Min ^*data from raw suppliers

GDP-L-galactose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GDP-L-Galactose

There total 23 articles about GDP-L-Galactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

D-Mannose (530-26-7) + Guanosine 5'-triphosphate (86-01-1,72490-81-4) → guanosine-5'-diphosphate (146-91-8) + guanosine 5'-diphospho-D-mannose (991-43-5,3123-67-9,5572-04-3,5750-57-2,6815-91-4,10108-97-1,20236-92-4,20406-59-1,26234-84-4,26378-86-9,41432-88-6,55331-69-6,78391-95-4)

Guidance literature:

With guanosine 50-diphosphate (GDP)-mannose pyrophosphorylasefrom Pyrococcus furiosus; N-acetylhexosamine 1-kinase from Bifidobacterium infantis; magnesium chloride; Escherichia coli inorganic pyrophosphatase; In aq. buffer; at 37 ℃; for 24h; pH=8; Enzymatic reaction;

DOI:10.1021/ol402585c

Reference yield: 54.0%

α-mannose 1-phosphate dicyclohexylammonium salt (50615-45-7,50820-78-5,72946-45-3,77895-07-9) + Guanosine 5'-triphosphate (36051-31-7) → guanosine 5'-diphospho-D-mannose (991-43-5,3123-67-9,5572-04-3,5750-57-2,6815-91-4,10108-97-1,20236-92-4,20406-59-1,26234-84-4,26378-86-9,41432-88-6,55331-69-6,78391-95-4)

Guidance literature:

With ethylenediaminetetraacetic acid; GDP-mannose pyrophosphorylase; sodium fluoride; magnesium chloride; for 24h; Ambient temperature; pH 7.5;

DOI:10.1021/jo00293a030

Reference yield: 40.0%

α-D-mannose 1-phosphate mono-triethylammonium salt (139883-95-7) + guanosine 5'-monophosphate dibutylphosphinothioic anhydride tributylammonium salt → guanosine 5'-diphospho-D-mannose (991-43-5,3123-67-9,5572-04-3,5750-57-2,6815-91-4,10108-97-1,20236-92-4,20406-59-1,26234-84-4,26378-86-9,41432-88-6,55331-69-6,78391-95-4)

Guidance literature:

With silver(I) acetate; In pyridine; for 4h;

upstream raw materials:

Guanosine 5'-triphosphate

mannose-1-phosphate

α-mannose 1-phosphate dicyclohexylammonium salt

Guanosine 5'-triphosphate

Downstream raw materials:

GDP-L-gulose

guanosine 5’-diphospho-β-L-fucose

guanosine-5'-diphosphate

[3''-2H]-GDP-6-deoxy-4-keto-D-mannose

Refernces

• 1、 Chen, Zonggang,Gu, Guofeng,Jin, Guoxia,Li, Siqiang,Wang, Hong. "Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from: Streptococcus pneumonia serotype 23F". . p. 30110 - 30114. Retrieved 2020/09/07.
• 2、 Li, Lei,Liu, Yonghui,Wan, Yue,Li, Yanhong,Chen, Xi,Zhao, Wei,Wang, Peng George. "Efficient enzymatic synthesis of guanosine 5′-diphosphate-sugars and derivatives". supporting information. p. 5528 - 5530. Retrieved 2013/11/19.