3-Azaspiro[5.5]undecane

Base Information

• Chemical Name: 3-Azaspiro[5.5]undecane
• CAS No.: 180-44-9
• Molecular Formula: C10H19N
• Molecular Weight: 153.268
• Hs Code.: 2933990090
• Mol file: 180-44-9.mol

Synonyms:4,4-Pentamethylenepiperidine;4,4-Spiro[pentamethylenepiperidine];Piperidine, 4,4-(1,5-pentanediyl)-;

Chemical Property of 3-Azaspiro[5.5]undecane

Chemical Property:

• Vapor Pressure: 0.0973mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 223.2 °C at 760 mmHg
• PKA: 11.17±0.20(Predicted)
• Flash Point: 86.7 °C
• PSA: 12.03000
• Density: 0.93 g/cm³
• LogP: 2.64910
• Storage Temp.: Desiccate at RT

Purity/Quality:

99%, ^*data from raw suppliers

4,4-Pentamethylenepiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,4-Pentamethylenepiperidine is an M2 proton channel blocker. It is salt free form of 4,4-Pentamethylenepiperidine Hydrochloride (P271760).

Technology Process of 3-Azaspiro[5.5]undecane

There total 4 articles about 3-Azaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tetramethylene glutarimide (1075-89-4) → 3-azaspiro[5.5]undecane (180-44-9)

Guidance literature:

In tetrahydrofuran;

Reference yield: 71.0%

→ 3-azaspiro[5.5]undecane (180-44-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; water; at 0 - 10 ℃; for 3h; Reflux;

Reference yield:

3-benzyl-3-azaspiro[5.5]undecane (4375-49-9) → 3-azaspiro[5.5]undecane (180-44-9)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 4h;

upstream raw materials:

3-benzyl-3-azaspiro[5.5]undecane

tetramethylene glutarimide

3-azaspiro[5.5]undecane-2,4-dione

Downstream raw materials:

(R)-5-(3-Aza-spiro[5.5]undec-3-yl)-4-benzyloxycarbonylamino-5-oxo-pentanoic acid benzyl ester

3-(pyridin-2-ylmethyl)-3-azaspiro[5.5]undecane

3-(thiophen-3-ylmethyl)-3-azaspiro[5.5]undecane

3-((1-methyl-1H-pyrazol-4-yl)methyl)-3-azaspiro[5.5]undecane

Refernces

• 1、 -. "Compound as potassium channel modulator". Paragraph 0211; 1017; 1019; 1020; 1021. . Retrieved 2018/07/30.
• 2、 -. "SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF". Page/Page column 40. . Retrieved 2010/11/30.