1-(3-Bromophenyl)-1H-pyrrole

Base Information

• Chemical Name: 1-(3-Bromophenyl)-1H-pyrrole
• CAS No.: 107302-22-7
• Molecular Formula: C10H8 Br N
• Molecular Weight: 222.084
• Hs Code.: 2933990090
• Mol file: 107302-22-7.mol

Synonyms:1-(3-Bromophenyl)-1H-pyrrole;1-(m-Bromophenyl)pyrrole; 3-(1-Pyrrolyl)bromobenzene

Chemical Property of 1-(3-Bromophenyl)-1H-pyrrole

Chemical Property:

• Vapor Pressure: 0.00277mmHg at 25°C
• Melting Point: 63-64 ºC
• Boiling Point: 294.9°Cat760mmHg
• PKA: -5.74±0.70(Predicted)
• Flash Point: 132.2°C
• PSA: 4.93000
• Density: 1.38g/cm³
• LogP: 3.23980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Bromophenyl)-1H-pyrrole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Bromophenyl)-1H-pyrrole

There total 4 articles about 1-(3-Bromophenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + m-Bromoaniline (591-19-5) → 1-(3-bromophenyl)-1H-pyrrole (107302-22-7)

Guidance literature:

With acetic acid; Reflux;

DOI:10.14233/ajchem.2013.13307

Reference yield: 79.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + m-Bromoaniline (591-19-5) → 1-(3-bromophenyl)-1H-pyrrole (107302-22-7) + 1-(3-bromophenyl)-pyrrolidine (219928-13-9)

Guidance literature:

With sodium tetrahydroborate; sulfuric acid; water; In tetrahydrofuran; methanol; at 10 - 20 ℃; for 1.5h; Yield given;

DOI:10.1055/s-1999-3685

Reference yield: 75.0%

pyrrole (109-97-7,30604-81-0) + 1-Bromo-3-iodobenzene (591-18-4) → 1-(3-bromophenyl)-1H-pyrrole (107302-22-7)

Guidance literature:

With 1,2-ethanedione dioxime; tetrabutylammomium bromide; copper(l) chloride; sodium hydroxide; In water; at 100 ℃; for 24h; Inert atmosphere; sealed tube;

DOI:10.1039/c002172e

upstream raw materials:

meso-galactaric acid

m-Bromoaniline

cis,trans-2,5-dimethoxytetrahydrofuran

pyrrole

Downstream raw materials:

2-(3-bromo-phenyl)-pyrrole

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[3-(1H-pyrrol-1-yl)phenyl]-1-benzothiophene-2-carboxamide hydrochloride

1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-pyrrole

1-phenylpyrrole

Refernces

• 1、 Faigl, Ferenc,Deák, Szilvia,Mucsi, Zoltán,Hergert, Tamás,Balázs, László,Sándor, Boros,Balázs, Barbara,Holczbauer, Tamás,Nyerges, Miklós,Mátrav?lgyi, Béla. "A novel and convenient method for the preparation of 5-(diphenylmethylene)-1H-pyrrol-2(5H)-ones; synthesis and mechanistic study". . p. 5444 - 5455. Retrieved 2016/08/04.
• 2、 Lee,Lee,Jung,Hahn. "Synthesis of heteroaromatic derivatives with nitrogen atoms: Tripyrrolyl pyrimidine and tripyrrolyl[1,3,5]triazine". . p. 501 - 504. Retrieved 2013/02/22.