2-Bromopropionyl bromide

Base Information

• Chemical Name: 2-Bromopropionyl bromide
• CAS No.: 563-76-8
• Deprecated CAS: 95673-15-7
• Molecular Formula: C3H4Br2O
• Molecular Weight: 215.872
• Hs Code.: 29159000
• European Community (EC) Number: 209-261-7
• DSSTox Substance ID: DTXSID00862201
• Nikkaji Number: J438C
• Mol file: 563-76-8.mol

Synonyms:Propionylbromide, 2-bromo- (6CI,7CI);2-Bromopropanoyl bromide;DL-2-Bromopropionyl bromide;a-Bromopropanyl bromide;a-Bromopropionyl bromide;

Chemical Property of 2-Bromopropionyl bromide

Chemical Property:

• Appearance/Colour: Pale yellow transparent liquid
• Vapor Pressure: 1.3 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.518(lit.)
• Boiling Point: 154.6 °C at 760 mmHg
• Flash Point: 66.5 °C
• PSA: 17.07000
• Density: 2.118 g/cm³
• LogP: 1.69130
• Sensitive.: Moisture Sensitive
• Solubility.: Miscible with trichloromethane, diethyl ether, benzene and aceto
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 215.86084
• Heavy Atom Count: 6
• Complexity: 61.8

Purity/Quality:

99% ^*data from raw suppliers

2-Bromopropionyl bromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(=O)Br)Br
• Uses: 2-Bromopropionyl bromide is used in the preparation of cellulose macroinitiator through direct acylation of cellulose in ionic liquid 1-allyl-3-methylimidazolium chloride. It is also used to prepare 3-(2-bromopropionyl)-2-oxazolidone derivatives and bromoester terminated poly(3-hexylthiophene). Further, it is used as a macroinitiator for atom transfer radical polymerization of acrylates. 2-Bromopropionyl bromide has been used in the synthesis of:cellulose macroinitiator via direct acylation of cellulose in ionic liquid 1-allyl-3-methylimidazolium chloride3-(2-bromopropionyl)-2-oxazolidone derivativesbromoester terminated poly(3-hexylthiophene), used as macroinitiator for atom transfer radical polymerization of acrylates.

Technology Process of 2-Bromopropionyl bromide

There total 14 articles about 2-Bromopropionyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ α-bromopropionyl bromide (563-76-8)

Guidance literature:

Reference yield:

1,1-dibromopropene (13195-80-7) → α-bromopropionyl bromide (563-76-8)

Guidance literature:

With oxygen; at 20 ℃;

Reference yield:

propionic acid (802294-64-0,79-09-4) → α-bromopropionyl bromide (563-76-8)

Guidance literature:

With phosphorus; bromine; zuletzt unter Erwaermen;

upstream raw materials:

1,1-dibromopropene

propanoyl bromide

propionyl chloride

propionic acid

Downstream raw materials:

2-bromo-1-(pyrrolidin-1-yl)propan-1-one

Methyl 2-bromopropionate

[4-(2-chloro-propionyl)-phenyl]-acetic acid

[4-(2-bromo-propionylamino)-phenyl]-arsonic acid

Refernces

• 1、 Hu, Bei,Chen, Haixia,Liu, Yan,Dong, Wuheng,Ren, Kai,Xie, Xiaomin,Xu, Hao,Zhang, Zhaoguo. "Visible light-induced intermolecular radical addition: Facile access to γ-ketoesters from alkyl-bromocarboxylates and enamines". supporting information. p. 13547 - 13550. Retrieved 2015/01/09.
• 2、 -. "Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs". . . Retrieved 2008/06/13.