H-ASP(OBZL)-OBZL HCL

Base Information

• Chemical Name: H-ASP(OBZL)-OBZL HCL
• CAS No.: 6327-59-9
• Molecular Formula: C18H19NO4^.HCl
• Molecular Weight: 349.814
• Hs Code.: 2922499990
• Mol file: 6327-59-9.mol

Synonyms:Asparticacid, dibenzyl ester, hydrochloride (6CI);L-Aspartic acid, bis(phenylmethyl)ester, hydrochloride (9CI);Dibenzyl aspartate hydrochloride;NSC 50875;H-ASP(OBZL)-OBZL.HCL;

Chemical Property of H-ASP(OBZL)-OBZL HCL

Chemical Property:

• Vapor Pressure: 1.78E-08mmHg at 25°C
• Melting Point: 124-125 °C
• Refractive Index: 1.574
• Boiling Point: 455.3°C at 760 mmHg
• Flash Point: 180.6°C
• PSA: 78.62000
• Density: 1.205g/cm³
• LogP: 3.69290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

H-Asp(OBzl)-Obzl HCl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ASP(OBZL)-OBZL HCL

There total 6 articles about H-ASP(OBZL)-OBZL HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + benzyl alcohol (100-51-6,185532-71-2) → L-aspartic acid dibenzyl ester hydrochloride (6327-59-9,174457-99-9)

Guidance literature:

L-Aspartic acid; benzyl alcohol; at 20 - 90 ℃;

With sodium carbonate; In water; pH=10;

With hydrogenchloride; In diethyl ether;

DOI:10.1016/j.bmc.2010.07.043

Reference yield:

dibenzyl L-aspartate toluene-4-sulphonate (2886-33-1) → L-aspartic acid dibenzyl ester hydrochloride (6327-59-9,174457-99-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / CuCO₃*Cu(OH)2 / ethanol; H₂O / 2 h / 70 °C

2: 90 percent / Et₃N / H₂O; tetrahydrofuran / 12 h / Ambient temperature

4: HCl

With hydrogenchloride; triethylamine; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jo00061a006

Reference yield:

toluene-4-sulfonic acid (104-15-4) → L-aspartic acid dibenzyl ester hydrochloride (6327-59-9,174457-99-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / benzene / 3.5 h / Heating

2: 98 percent / CuCO₃*Cu(OH)2 / ethanol; H₂O / 2 h / 70 °C

3: 90 percent / Et₃N / H₂O; tetrahydrofuran / 12 h / Ambient temperature

5: HCl

With hydrogenchloride; triethylamine; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1021/jo00061a006

upstream raw materials:

(S)-N-tert-butyloxycarbonylaspartic acid dibenzyl ester

BOC-L-aspartic acid 4-benzyl ester

dibenzyl L-aspartate toluene-4-sulphonate

toluene-4-sulfonic acid

Downstream raw materials:

(S)-2-{(S)-4-Benzyloxycarbonyl-4-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-succinic acid dibenzyl ester

(S)-2-{(S)-4-Benzyloxycarbonyl-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-succinic acid dibenzyl ester

(1R,2R,6R,8R,12S,14S)-12-benzyloxycarbonylmethyl-10,13-diaza-4,4-dimethyl-16,16-dioxide-11-oxo-3,5,7,17-tetraoxa-16-thio-pentacyclo[9.6.0.0^2,6.0^1,14.0^10,14]heptadecane

N-(3-benzyloxycarbonyl-β-carbolin-1-yl)ethyl-L-aspartic acid dibenzyl ester

Refernces

• 1、 Bergmeier, Stephen C.,Cobas, Agustin A.,Rapoport, Henry. "Chirospecific Synthesis of (1S,3R)-1-Amino-3-(hydroxymethyl)cyclopentane, Precursor for Carbocyclic Nucleoside Synthesis. Dieckmann Cyclization with an α-Amino Acid". . p. 2369 - 2376. Retrieved 2007/10/02.