4-Methylacridine

Base Information

• Chemical Name: 4-Methylacridine
• CAS No.: 610-51-5
• Molecular Formula: C14H11N
• Molecular Weight: 193.248
• Hs Code.: 2933990090
• European Community (EC) Number: 210-226-3
• DSSTox Substance ID: DTXSID10209860
• Nikkaji Number: J55.105H
• Wikidata: Q83084329
• ChEMBL ID: CHEMBL1702084
• Mol file: 610-51-5.mol

Synonyms:4-Methylacridine;ACRIDINE, 4-METHYL-;610-51-5;4-Methylakridin;4-Methylakridin [Czech];1-Methylacridine (European);BRN 0005682;EINECS 210-226-3;5-20-08-00252 (Beilstein Handbook Reference);Acridine,4-methyl-;MLS001178994;SCHEMBL1188539;CHEMBL1702084;DTXSID10209860;HMS2806K14;AKOS006279835;NCGC00186403-01;SMR000477011;AM-944/40947606

Chemical Property of 4-Methylacridine

Chemical Property:

• Vapor Pressure: 4.19E-05mmHg at 25°C
• Melting Point: 114 °C
• Refractive Index: 1.703
• Boiling Point: 361.9 °C at 760 mmHg
• PKA: 5.61±0.10(Predicted)
• Flash Point: 160 °C
• PSA: 12.89000
• Density: 1.155 g/cm³
• LogP: 3.69640
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 193.089149355
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

99%, ^*data from raw suppliers

5-METHYLACRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC2=CC3=CC=CC=C3N=C12

Technology Process of 4-Methylacridine

There total 33 articles about 4-Methylacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 4-methyl-acridine (610-51-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; In toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;

In toluene; at 80 ℃; for 12h;

Reference yield: 34.0%

2,6-dimethylphenyl 2-azidobenzoate (76943-53-8) → 4-methyl-9,10-dihydroacridine (76943-54-9) + 4-methyl-acridine (610-51-5)

Guidance literature:

at 320 ℃; under 1 - 2 Torr;

Reference yield: 32.0%

1-(2,6-dimethylphenyl)-1H-benzo[d][1,2,3]triazole (82757-38-8) → 1,9-dimethyl-9H-carbazole (14171-85-8) + 1,8-dimethyl-9H-carbazole (6558-83-4) + 4-methyl-acridine (610-51-5) + 1-methyl-9H-carbazole (6510-65-2)

Guidance literature:

at 640 ℃; under 0.03 Torr; Further byproducts given;

upstream raw materials:

4-methyl-9,10-dihydroacridine

2-methylphenyl bromide

o-aminobenzaldehyde

1-(2,6-dimethylphenyl)-1H-benzo[d][1,2,3]triazole

Downstream raw materials:

10H-acridin-9-one

Refernces

• 1、 Hu, Weiming,Zheng, Qingheng,Sun, Song,Cheng, Jiang. "Rh(III)-Catalyzed bilateral cyclization of aldehydes with nitrosos toward unsymmetrical acridines proceeding with C-H functionalization enabled by a transient directing group". supporting information. p. 6263 - 6266. Retrieved 2017/07/07.
• 2、 Wang, Ting-Jun,Chen, Wen-Wen,Li, Yi,Xu, Ming-Hua. "Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol". . p. 6580 - 6586. Retrieved 2015/06/16.