(5Z)-7-[(1α,4α)-3β-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid

Base Information Edit

Chemical Name:(5Z)-7-[(1α,4α)-3β-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid
CAS No.:82337-14-2
Molecular Formula:C21H34O4
Molecular Weight:350.499
Hs Code.:
Mol file:82337-14-2.mol

Synonyms:15-epi-9a-homo-(11,12)-deoxathromboxane A2;(Z)-7-[(1S,2R,3R,4R)-3-((E)-(S)-3-Hydroxy-oct-1-enyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5Z)-7-[(1α,4α)-3β-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid Edit

Chemical Property:

PSA：66.76000
LogP:4.47860

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5Z)-7-[(1α,4α)-3β-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid

There total 24 articles about (5Z)-7-[(1α,4α)-3β-[(1E,3S)-3-Hydroxy-1-octenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 98717-92-1
<1S-(1α,2β(5Z),3α(1E,3S^*),4α)>-7-<3-(3-hydroxy-1-octenyl)-7-oxabicyclo<2.2.1>heptan-2-yl>-5-heptanoic acid methyl ester

: 82337-14-2
SQ 26655

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 - 25 ℃; for 5h;
DOI:10.1021/jm00149a007

Reference yield:

: 6118-51-0
exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

: 82337-14-2
SQ 26655

Guidance literature:: Multi-step reaction with 13 steps

1: 72.8 percent / sodium borohydride / ethanol / 2 h / 20 °C

2: 95.3 percent / H₂ / 5percent palladium-carbon / methanol / 24 h / Ambient temperature

3: dimethylsulfoxide / 4.5 h / 190 °C

4: 62.7 percent / diethyl ether / 3 h / Ambient temperature

5: 97.1 percent / potassium carbonate / methanol / 4 h / 0 °C

6: 14.7 percent / diisobutylaluminium hydride / hexane; toluene / 2 h / -60 °C

8: 1) 50percent sodium hydride / 1) benzene, 10 min, RT, 2) benzene, 2 h, RT

9: 100 percent / sodium borohydride / methanol / 1 h / 0 °C

10: 100 percent / p-toluenesulfonic acid / CH₂Cl₂ / 2 h / 0 °C

11: 98 mg / diisobutylaluminium hydride / toluene / 4 h / -60 °C

13: 9 mg / acetic acid; H₂O; tetrahydrofuran / 2.5 h / 40 °C

With sodium tetrahydroborate; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; acetic acid; dimethyl sulfoxide; toluene;
DOI:10.1248/cpb.30.796