3-(4-ETHYLBENZOYL)PROPIONIC ACID

Base Information

• Chemical Name: 3-(4-ETHYLBENZOYL)PROPIONIC ACID
• CAS No.: 49594-75-4
• Molecular Formula: C12H14 O3
• Molecular Weight: 206.241
• Hs Code.: 2918300090
• Mol file: 49594-75-4.mol

Synonyms:Propionicacid, 3-p-ethylbenzoyl- (6CI); 3-(4-Ethylbenzoyl)propionic acid;4-(4-Ethylphenyl)-4-oxobutanoic acid; NSC 246068; b-(4-Ethylbenzoyl)propionic acid; b-(p-Ethylbenzoyl)propionic acid

Chemical Property of 3-(4-ETHYLBENZOYL)PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 4.56E-07mmHg at 25°C
• Melting Point: 92-94oC
• Boiling Point: 398.6°Cat760mmHg
• Flash Point: 209°C
• PSA: 54.37000
• Density: 1.136g/cm³
• LogP: 2.29650

Purity/Quality:

99% ^*data from raw suppliers

4-Ethyl-γ-oxobenzenebutanoicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Ethyl-γ-oxobenzenebutanoic Acid is a useful reagent in preparation of 1,8-naphthyridinyl-3(2H)-pyridazinones in dry media under microwave irradiation using zeolite-HY supported on silica gel catalyst.

Technology Process of 3-(4-ETHYLBENZOYL)PROPIONIC ACID

There total 4 articles about 3-(4-ETHYLBENZOYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

succinic acid anhydride (108-30-5) + ethylbenzene (100-41-4,27536-89-6) → 4-(4-ethylphenyl)-4-oxobutyric acid (49594-75-4)

Guidance literature:

With aluminium trichloride; at 20 ℃; for 0.2h;

DOI:10.1081/SCC-120023423

Reference yield:

succinic acid anhydride (108-30-5) + Phenetole (103-73-1) → 4-(4-ethylphenyl)-4-oxobutyric acid (49594-75-4)

Guidance literature:

With aluminum (III) chloride; for 6h; Reflux;

DOI:10.1016/j.bioorg.2020.104458

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + succinoyl dichloride (543-20-4) → 4-(4-ethylphenyl)-4-oxobutyric acid (49594-75-4)

Guidance literature:

Multistep reaction; (i) iBuAlCl₂, (ii) AlCl₃, (iii) /BRN= 507064/, CH₂Cl₂;

upstream raw materials:

succinic acid anhydride

ethylbenzene

styrene

succinoyl dichloride

Downstream raw materials:

3-(4-ethylbenzoyl)-3-butenoic acid

Refernces

• 1、 Khisal, Subuhi,Mishra, Ravinesh,Partap, Sangh,Siddiqui, Aness Ahmad,Yar, Mohammad Shahar. "Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues". . . Retrieved 2020/04/07.
• 2、 Sharma, Bhawna,Verma, Amita,Sharma, Upendra Kumar,Prajapati, Sunil. "Efficient synthesis, anticonvulsant and muscle relaxant activities of new 2-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-6-phenyl-4,5-dihydropyridazin-3(2H) -one derivatives". . p. 146 - 157. Retrieved 2014/03/21.