Quinoline-2-carboxylic acid hydrochloride

Base Information

• Chemical Name: Quinoline-2-carboxylic acid hydrochloride
• CAS No.: 89047-45-0
• Molecular Formula: C₁₀H₇NO₂*ClH
• Molecular Weight: 209.632
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70482091
• Mol file: 89047-45-0.mol

Synonyms:Quinoline-2-carboxylic acid hydrochloride;89047-45-0;quinoline-2-carboxylic acid;hydrochloride;Quinoline-2-carboxylicacidhydrochloride;SCHEMBL2372429;DTXSID70482091;SB69138;quinoline carboxylic acid monohydrochloride;CS-0311480;FT-0730489;Quinoline-2-carboxylic acid--hydrogen chloride (1/1)

Chemical Property of Quinoline-2-carboxylic acid hydrochloride

Chemical Property:

• PSA: 50.19000
• LogP: 2.73500
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 209.0243562
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

98%,99%, ^*data from raw suppliers

Quinoline-2-carboxylicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C(=O)O.Cl

Technology Process of Quinoline-2-carboxylic acid hydrochloride

There total 1 articles about Quinoline-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinoline-2-carboxylic acid (93-10-7,1199266-78-8) → quinoline-2-carboxylic acid hydrochloride (89047-45-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; pH=1;

DOI:10.1055/s-0029-1218701

Reference yield: 81.0%

quinoline-2-carboxylic acid hydrochloride (89047-45-0) → 1,2,3,4-tetrahydroquinoline-2-carboxylic acid (46185-24-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 60 ℃; for 2h; under 3102.9 Torr;

DOI:10.1021/jo00289a058

Reference yield:

quinoline-2-carboxylic acid hydrochloride (89047-45-0) → 3,4-Dihydro-2H-quinoline-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine (123811-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / hydrogen / platinum oxide / acetic acid / 2 h / 60 °C / 3102.9 Torr

2: 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5

3: diethyl ether / 4 h

With sodium hydroxide; hydrogen; platinum(IV) oxide; In diethyl ether; acetic acid; tert-butyl alcohol;

DOI:10.1021/jo00289a058

upstream raw materials:

quinoline-2-carboxylic acid

Downstream raw materials:

1,2,3,4-tetrahydroquinoline-2-carboxylic acid

1-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

3,4-Dihydro-2H-quinoline-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine

Refernces