Uridine, 5-[[methyl(trifluoroacetyl)amino]methyl]-2-thio-, 2',3',5'-tribenzoate

Base Information

• Chemical Name: Uridine, 5-[[methyl(trifluoroacetyl)amino]methyl]-2-thio-, 2',3',5'-tribenzoate
• CAS No.: 89128-97-2
• Molecular Formula: C₃₄H₂₈F₃N₃O₉S
• Molecular Weight: 711.672
• Mol file: 89128-97-2.mol

Synonyms:

Chemical Property of Uridine, 5-[[methyl(trifluoroacetyl)amino]methyl]-2-thio-, 2',3',5'-tribenzoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Uridine, 5-[[methyl(trifluoroacetyl)amino]methyl]-2-thio-, 2',3',5'-tribenzoate

There total 1 articles about Uridine, 5-[[methyl(trifluoroacetyl)amino]methyl]-2-thio-, 2',3',5'-tribenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 2,2,2-Trifluoro-N-methyl-N-(4-trimethylsilanyloxy-2-trimethylsilanylsulfanyl-pyrimidin-5-ylmethyl)-acetamide → C34H28F3N3O9S (89128-97-2)

Guidance literature:

With tin(IV) chloride; In acetonitrile; Yield given;

DOI:10.1016/S0040-4039(00)87876-4

Reference yield:

C34H28F3N3O9S (89128-97-2) → 2,2,2-Trifluoro-N-{1-[(2R,3R,4R,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-(4-methoxy-tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl}-N-methyl-acetamide

Guidance literature:

Multi-step reaction with 5 steps

1: 20 percent / Na methoxide / methanol / 0 °C

2: pyridine

3: p-toluenesulfonic acid

4: F(-)

With fluoride; sodium methylate; toluene-4-sulfonic acid; In pyridine; methanol;

DOI:10.1016/S0040-4039(00)87876-4

Reference yield:

C34H28F3N3O9S (89128-97-2) → 2-thio-5-<(methylamino)methyl>uridine (32860-54-1)

Guidance literature:

With ammonium hydroxide; In methanol; at 0 ℃;

DOI:10.1016/S0040-4039(00)87876-4

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

Downstream raw materials:

2-thio-5-<(methylamino)methyl>uridine

Refernces