4-METHOXY-2(5H)-FURANONE

Base Information

• Chemical Name: 4-METHOXY-2(5H)-FURANONE
• CAS No.: 69556-70-3
• Molecular Formula: C5H6O3
• Molecular Weight: 114.101
• Hs Code.: 29322090
• Mol file: 69556-70-3.mol

Synonyms:4-Methoxy-5H-furan-2-one;4-Methoxy-2(5H)-furanone;Methyl tetronate;4-methoxyfuran-2(5H)-one;2(5H)-Furanone, 4-methoxy-;3-methoxy-2H-furan-5-one;

Chemical Property of 4-METHOXY-2(5H)-FURANONE

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: 0.000834mmHg at 25°C
• Melting Point: 62-64 °C(lit.)
• Refractive Index: 1.465
• Boiling Point: 305.2 °C at 760 mmHg
• Flash Point: 120.4 °C
• PSA: 35.53000
• Density: 1.19 g/cm³
• LogP: 0.07350

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methyl-furan-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxy-2(5H)-furanone may be used as starting reagent in the synthesis of 5-alkylidene 4-methoxy-2(5H)-furanone.

Technology Process of 4-METHOXY-2(5H)-FURANONE

There total 11 articles about 4-METHOXY-2(5H)-FURANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Methoxymaleinsaeureanhydrid (69945-03-5) → 4-methoxy-5H-furan-2-one (69556-70-3)

Guidance literature:

With lithium aluminium tetrahydride;

Reference yield: 91.0%

(E)-4-chloro-3-methoxy-but-2-enoic acid methyl ester (110104-60-4,85153-60-2) → 4-methoxy-5H-furan-2-one (69556-70-3)

Guidance literature:

In neat (no solvent); at 200 - 205 ℃; for 5h;

DOI:10.1055/s-1992-26120

Reference yield: 75.0%

methanol (67-56-1) + 4-hydroxy-2(5H)-furanone (541-57-1) → 4-methoxy-5H-furan-2-one (69556-70-3)

Guidance literature:

With acetyl chloride; for 4h; Heating;

upstream raw materials:

diazomethane

tetrahydrofuran-2,4-dione

methanol

4-hydroxy-2(5H)-furanone

Downstream raw materials:

(5RS)-5-[(RS/SR)-1-hydroxybenzyl]-4-methoxyfuran-2(5H)-one

(Z)-4-methoxy-5-benzylidenefuran-2(5H)-one

4-Methoxy-5-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-5H-furan-2-one

methyl 5-(1'-methoxy-3'-phenylpropyl)tetronate

Refernces

• 1、 Rosario Martin,Victoria Martin,De Guere?u, Ana Martinez,Luis Ortego. "Pseudoesters and derivatives xxxvi. reactions of enolates of 5-ethylthiofuran-2(5h)-ones with aromatic aldehydes: A synthesis of losigamone". . p. 191 - 198. Retrieved 1996.
• 2、 Paintner, Franz F.,Allmendinger, Lars,Bauschke, Gerd. "Highly efficient 4-O-alkylations of tetronic acids involving oxyphosphonium intermediates". . p. 83 - 86. Retrieved 2007/10/03.