4-(4-Morpholinyl)-picolinic acid

Base Information

• Chemical Name: 4-(4-Morpholinyl)-picolinic acid
• CAS No.: 66933-68-4
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.21
• Hs Code.: 2934999090
• European Community (EC) Number: 837-796-1
• DSSTox Substance ID: DTXSID90368782
• Wikidata: Q82155595
• Mol file: 66933-68-4.mol

Synonyms:66933-68-4;4-(4-Morpholinyl)-picolinic acid;4-morpholin-4-ylpyridine-2-carboxylic acid;4-Morpholinopicolinic acid;4-(morpholin-4-yl)pyridine-2-carboxylic acid;4-Morpholino-2-pyridinecarboxylic acid;4-Morpholinopicolinicacid;SCHEMBL10098367;DTXSID90368782;MFCD06382849;AKOS000118433;WAY-643631;NCGC00325593-01;TS-00402;4-Morpholin-1-ylpyridine-2-carboxylic acid;2-Pyridinecarboxylicacid,4-(4-morpholinyl)-;4-(4-morpholinyl)pyridine-2-carboxylic acid;CS-0155587;FT-0715931;EN300-12115;D94804;AB01320937-02;SR-01000063861;SR-01000063861-1;Z57983015;4-(4-morpholinyl)-pyridine-2-carboxylic acid, AldrichCPR

Chemical Property of 4-(4-Morpholinyl)-picolinic acid

Chemical Property:

• Vapor Pressure: 4.91E-09mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 454.1 °C at 760 mmHg
• Flash Point: 228.4 °C
• PSA: 62.66000
• Density: 1.313 g/cm³
• LogP: 0.68140
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 208.08479225
• Heavy Atom Count: 15
• Complexity: 229

Purity/Quality:

98% ^*data from raw suppliers

4-Morpholino-2-pyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC(=NC=C2)C(=O)O

Technology Process of 4-(4-Morpholinyl)-picolinic acid

There total 6 articles about 4-(4-Morpholinyl)-picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(morpholin-4-yl)pyridine-4-carboxylate (83728-67-0) → 4-morpholin-4-yl-pyridine-2-carboxylic acid (66933-68-4)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 7h;

Reference yield:

4-chloropicolinic acid (5470-22-4) → 4-morpholin-4-yl-pyridine-2-carboxylic acid (66933-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / tetrahydrofuran / 0 - 20 °C

2: 110 °C

3: hydrogenchloride; water / 7 h / 110 °C

With hydrogenchloride; methanol; water; In tetrahydrofuran;

Reference yield:

N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide (82776-75-8) → 4-morpholin-4-yl-pyridine-2-carboxylic acid (66933-68-4) + N-cyclopentylbenzamide (53226-42-9)

Guidance literature:

With water; In acetone; for 200h; Ambient temperature;

upstream raw materials:

morpholine

4-Chloro-pyridine-2-carboxylic acid methyl ester

methanol

N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide

Downstream raw materials:

N-(4-Morpholin-4-yl-pyridine-2-carbonyl)-N-pyridin-2-yl-benzamide

N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide

4-morpholin-4-yl-N-(4-nitro-phenyl)-pyridine-2-carboximidoyl chloride

4-morpholin-4-yl-pyridine-2-carboxylic acid anilide

Refernces

• 1、 Morkved, Eva H.,Cronyn, Marshall W.. "Potential Acyl-transfer Agents. Reactions of N-Acyl-2-pyridinecarboxamides with Nucleophiles". . p. 381 - 388. Retrieved 2007/10/02.