2-Iodo-4-nitrobenzoic acid

Base Information

• Chemical Name: 2-Iodo-4-nitrobenzoic acid
• CAS No.: 89459-38-1
• Molecular Formula: C7H4INO4
• Molecular Weight: 293.018
• Hs Code.: 2916399090
• Mol file: 89459-38-1.mol

Synonyms:Benzoic acid,2-iodo-4-nitro;Benzoic acid, 2-iodo-4-nitro-;4-nitro-2-iodobenzoic acid;2-Jod-4-nitro-benzoesaeure;2-iodo-4-nitro-benzoic acid;

Chemical Property of 2-Iodo-4-nitrobenzoic acid

Chemical Property:

• Melting Point: 142 °C
• Boiling Point: 402.8±35.0 °C(Predicted)
• PKA: 1.99±0.13(Predicted)
• PSA: 83.12000
• Density: 2.156±0.06 g/cm3(Predicted)
• LogP: 2.42080
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Iodo-4-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 2-Iodo-4-nitrobenzoic acid

There total 7 articles about 2-Iodo-4-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Nitroanthranilic acid (619-17-0) → 4-nitro-2-iodobenzoic acid (89459-38-1)

Guidance literature:

4-Nitroanthranilic acid; With toluene-4-sulfonic acid; In water; for 0.05h;

With sodium nitrite; In water; for 0.25h;

With potassium iodide; In water;

DOI:10.1021/acs.orglett.0c01685

Reference yield: 73.0%

4-nitro-2-iodosobenzoic acid (112391-34-1) → 4-nitro-2-iodobenzoic acid (89459-38-1)

Guidance literature:

With potassium iodide; In water; acetic acid; for 1h; Ambient temperature;

Reference yield: 45.0%

4-nitro-benzoic acid (62-23-7) → 4-nitro-2-iodobenzoic acid (89459-38-1)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; iodine; silver(I) acetate; triethylamine; at 23 ℃; for 18h; regioselective reaction; Sealed tube;

DOI:10.1002/chem.202002204

upstream raw materials:

2-iodo-1-methyl-4-nitrobenzene

4-nitro-2-iodosobenzoic acid

acetic anhydride

4-Nitroanthranilic acid

Refernces

• 1、 Hu, Ze-Nan,Shen, Hui-Jie,Zhang, Chi. "Singlet Oxygen Generation from a Water-Soluble Hypervalent Iodine(V) Reagent AIBX and H2O2: An Access to Artemisinin". supporting information. . Retrieved 2021/06/21.
• 2、 -. "5,8-DISUBSTITUTED-[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL AND 5,8-DISUBSTITUTED-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ENTEROPEPTIDASE". Page/Page column 154. . Retrieved 2021/01/29.