N-(4-Methoxybenzyl)glycine

Base Information

• Chemical Name: N-(4-Methoxybenzyl)glycine
• CAS No.: 20839-78-5
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• NSC Number: 184721
• DSSTox Substance ID: DTXSID80306956
• Nikkaji Number: J1.515.572H
• Mol file: 20839-78-5.mol

Synonyms:N-(4-Methoxybenzyl)glycine;20839-78-5;2-((4-Methoxybenzyl)amino)acetic acid;2-[(4-methoxyphenyl)methylamino]acetic acid;Glycine, N-[(4-methoxyphenyl)methyl]-;HMS1510A11;(4-METHOXY-BENZYLAMINO)-ACETIC ACID;ChemDiv3_013035;SCHEMBL1807496;DTXSID80306956;BBL030007;MFCD03450579;NSC184721;STL372979;2-((4-Methoxybenzyl)amino)aceticacid;AKOS001585711;N-(4-Methoxybenzyl)glycine x0.13kcl;DS-3368;NSC-184721;NCGC00320095-01;CS-0373257;EU-0063316;D84316;AB01316817-02;SR-01000580538;SR-01000580538-1;2-{[(4-METHOXYPHENYL)METHYL]AMINO}ACETIC ACID

Chemical Property of N-(4-Methoxybenzyl)glycine

Chemical Property:

• Vapor Pressure: 1.47E-05mmHg at 25°C
• Boiling Point: 351.9°Cat760mmHg
• Flash Point: 166.6°C
• PSA: 58.56000
• Density: 1.174g/cm³
• LogP: 1.26030
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

90%,98% ^*data from raw suppliers

N-(4-Methoxybenzyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNCC(=O)O

Technology Process of N-(4-Methoxybenzyl)glycine

There total 4 articles about N-(4-Methoxybenzyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-methoxy-benzaldehyde (123-11-5) + glycine (56-40-6,18875-39-3,25718-94-9) → N-(4-methoxybenzyl)glycine (20839-78-5)

Guidance literature:

4-methoxy-benzaldehyde; glycine; In ethanol; for 2h;

With sodium tetrahydroborate; at 10 - 20 ℃;

DOI:10.1071/CH16150

Reference yield:

N-<4-Methoxy-benzyliden>-glycin (515158-60-8) → N-(4-methoxybenzyl)glycine (20839-78-5)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-(4-methoxybenzyl)glycine (20839-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 0.5 h / 20 °C

2: NaBH₄ / aq. NaOH / 0.5 h / 10 - 12 °C

With sodium hydroxide; sodium tetrahydroborate; In sodium hydroxide;

DOI:10.1016/S0040-4020(01)00315-5

upstream raw materials:

N-<4-Methoxy-benzyliden>-glycin

ethyl bromoacetate

4-methoxy-benzylamine

4-methoxy-benzaldehyde

Downstream raw materials:

N-(4-methoxy-benzyl)-N-nitroso-glycine

3-(4-methoxy-benzyl)-sydnone

1-allyl-2-(4-methoxyphenyl)-3-methyl-5-phenylthio-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine

N-4-methoxyphenylmethyliminodiacetic acid

Refernces

• 1、 Mahmud, Hossen,Lovely, Carl J,Rasika Dias. "An intramolecular azomethine ylide-alkene cycloaddition approach to pyrrolo[3,2-c]quinolines-synthesis of a C2-truncated martinelline model". . p. 4095 - 4105. Retrieved 2007/10/03.