4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE

Base Information

• Chemical Name: 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE
• CAS No.: 89720-77-4
• Molecular Formula: C7H5Br2Cl
• Molecular Weight: 284.378
• Hs Code.: 2903999090
• Mol file: 89720-77-4.mol

Synonyms:2-Chloro-4-bromobenzyl bromide;4-bromo-2-chlorobenzyl bromide;4-Bromo-1-bromomethyl-2-chlorobenzene;4-Bromo-2-chlorobenzylbromide;4-Bromo-1-bromomethyl-2-chloro-benzene;

Chemical Property of 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE

Chemical Property:

• PSA: 0.00000
• LogP: 3.99740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-1-bromomethyl-2-chlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-1-bromomethyl-2-chlorobenzene is used in the preparation of selective aldose reductase inhibitors.

Technology Process of 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE

There total 8 articles about 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-bromo-2-chlorophenyl)methanol (185315-48-4) → 4-bromo-1-bromomethyl-2-chlorobenzene (89720-77-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield: 80.0%

4-bromo-2-chlorotoluene (89794-02-5) → 4-bromo-1-bromomethyl-2-chlorobenzene (89720-77-4)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 18h; Heating / reflux;

Reference yield:

(4-bromo-2-chlorophenyl)methanol (185315-48-4) + potassium cyanide (151-50-8) → 4-bromo-1-bromomethyl-2-chlorobenzene (89720-77-4)

Guidance literature:

(4-bromo-2-chlorophenyl)methanol; With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

potassium cyanide; In ethanol; water; at 60 ℃; for 1.5h;

upstream raw materials:

4-bromo-2-chlorotoluene

(4-bromo-2-chlorophenyl)methanol

potassium cyanide

4-bromo-2-chlorobenzaldehyde

Downstream raw materials:

2-(4-bromo-2-chlorophenyl)acetonitrile

C₉H₉BrClNO₂

C₁₄H₁₇BrClNO₄

C₂₀H₂₃BrClNO₇

Refernces

• 1、 Koval, Alexander B.,Wuest, William M.. "An optimized synthesis of the potent and selective Pak1 inhibitor FRAX-1036". supporting information. p. 449 - 451. Retrieved 2016/01/12.
• 2、 Ndubaku, Chudi O.,Crawford, James J.,Drobnick, Joy,Aliagas, Ignacio,Campbell, David,Dong, Ping,Dornan, Laura M.,Duron, Sergio,Epler, Jennifer,Gazzard, Lewis,Heise, Christopher E.,Hoeflich, Klaus P.,Jakubiak, Diana,La, Hank,Lee, Wendy,Lin, Baiwei,Lyssikatos, Joseph P.,Maksimoska, Jasna,Marmorstein, Ronen,Murray, Lesley J.,O'Brien, Thomas,Oh, Angela,Ramaswamy, Sreemathy,Wang, Weiru,Zhao, Xianrui,Zhong, Yu,Blackwood, Elizabeth,Rudolph, Joachim. "Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety". supporting information. p. 1241 - 1246. Retrieved 2015/12/23.