1,4-Dioxaspiro[4.11]hexadecane

Base Information

• Chemical Name: 1,4-Dioxaspiro[4.11]hexadecane
• CAS No.: 650-06-6
• Molecular Formula: C14H26 O2
• Molecular Weight: 226.359
• European Community (EC) Number: 211-478-7
• UNII: 7B5EDJ9UTT
• DSSTox Substance ID: DTXSID80215317
• Nikkaji Number: J205.928B
• Wikidata: Q83091328
• Mol file: 650-06-6.mol

Synonyms:1,4-dioxaspiro[4.11]hexadecane;1,4-Dioxaspiro(4.11)hexadecane;650-06-6;EINECS 211-478-7;7B5EDJ9UTT;UNII-7B5EDJ9UTT;DTXSID80215317;CYCLODODECANONE, CYCLIC ETHYLENE ACETAL;CYCLODODECANONE, CYCLIC 1,2-ETHANEDIYL ACETAL

Chemical Property of 1,4-Dioxaspiro[4.11]hexadecane

Chemical Property:

• Vapor Pressure: 0.00599mmHg at 25°C
• Boiling Point: 281.7°C at 760 mmHg
• Flash Point: 112.9°C
• Density: 0.96g/cm³
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 226.193280068
• Heavy Atom Count: 16
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCCCCC2(CCCCC1)OCCO2

Technology Process of 1,4-Dioxaspiro[4.11]hexadecane

There total 4 articles about 1,4-Dioxaspiro[4.11]hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) + cyclododecanone (830-13-7) → cyclododecanone ethylene acetal (650-06-6)

Guidance literature:

With lithium perchlorate; In dichloromethane; for 1h; Ambient temperature; electrolysis (platinum electrodes, 10 V, 0.4-0.5 mA);

DOI:10.1246/cl.1983.1349

Reference yield: 88.0%

ethylene glycol (107-21-1) + cyclododecanone (830-13-7) → cyclododecanone ethylene acetal (650-06-6)

Guidance literature:

With dimethylbromosulphonium bromide; orthoformic acid triethyl ester; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200300685

Reference yield: 80.0%

6-bromo-1,4-dioxa-spiro[4.11]hexadecane (29047-14-1) → cyclododecanone ethylene acetal (650-06-6)

Guidance literature:

With triethyl borane; tri-n-butyl-tin hydride; In hexane; toluene; -78 deg C, 1 h then 20 deg C, 3 h;

DOI:10.1246/bcsj.62.143

upstream raw materials:

ethylene glycol

cyclododecanone

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

6-bromo-1,4-dioxa-spiro[4.11]hexadecane

Downstream raw materials:

2-hydroxyethyl-cyclododecyl-ether

cyclododecanone

methylenecyclodecane

2-(cyclododecyloxy)-1-<<(4-methylphenyl)sulfonyl>oxy>ethane

Refernces

• 1、 Fujita,S. et al.. "". . p. 2596 - 2598. Retrieved 1970.
• 2、 Thomas, Edward W.,Cudahy, Michele M.,Spilman, Charles H.,Dinh, Dac M.,Watkins, Tommie L.,Vidmar, Thomas J.. "Cholesterol Lowering Bile Acid Binding Agents: Novel Lipophilic Polyamines". . p. 1233 - 1245. Retrieved 2007/10/02.