L-Seryl azide, N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-tyrosyl]-

Base Information

• Chemical Name: L-Seryl azide, N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-tyrosyl]-
• CAS No.: 90072-08-5
• Molecular Formula: C₂₁H₂₃N₅O₇
• Molecular Weight: 457.443
• Mol file: 90072-08-5.mol

Synonyms:

Chemical Property of L-Seryl azide, N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-tyrosyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Seryl azide, N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-tyrosyl]-

There total 1 articles about L-Seryl azide, N-[N-[[(4-methoxyphenyl)methoxy]carbonyl]-L-tyrosyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z(OMe)-Tyr-Ser-NHNH2 (62074-72-0) → Z(OMe)-Tyr-Ser-N3 (90072-08-5)

Guidance literature:

With isopentyl nitrite; at 4 ℃;

DOI:10.1248/cpb.34.2397

Reference yield:

Z(OMe)-Tyr-Ser-N3 (90072-08-5) → H-Tyr-Ser-Ile-Ala-Met(O)-NHNH-Troc

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / Et₃N / dimethylformamide / 24 h

2: TFA, anisole / 1 h / 0 °C

With methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.34.2397

Reference yield:

Z(OMe)-Tyr-Ser-N3 (90072-08-5) → Z(OMe)-Asp(OChp)-Tyr-Ser-Ile-Ala-Met(O)-NHNH2 (108056-88-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / Et₃N / dimethylformamide / 24 h

2: TFA, anisole / 1 h / 0 °C

3: 54 percent / Et₃N, N-methylmorpholine / dimethylformamide / 3 h / 4 °C

4: 68 percent / Cd powder

With 4-methyl-morpholine; methoxybenzene; triethylamine; trifluoroacetic acid; cadmium; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.34.2397

upstream raw materials:

Z(OMe)-Tyr-Ser-NHNH₂

Downstream raw materials:

Z(OMe)-Asp(OChp)-Tyr-Ser-Ile-Ala-Met(O)-NHNH₂

Z(OMe)-Asp(OChp)-Tyr-Ser-Ile-Ala-Met(O)-NHNH-Troc

Refernces