Methyl thiazolidine-4-carboxylate

Base Information

• Chemical Name: Methyl thiazolidine-4-carboxylate
• CAS No.: 60667-24-5
• Molecular Formula: C5H9 N O2 S
• Molecular Weight: 147.198
• European Community (EC) Number: 262-361-2
• UNII: 8VLB09VT95
• DSSTox Substance ID: DTXSID10902920
• Nikkaji Number: J268.256G
• Wikidata: Q27271084
• Mol file: 60667-24-5.mol

Synonyms:4-carbomethoxythiazoline

Chemical Property of Methyl thiazolidine-4-carboxylate

Chemical Property:

• Boiling Point: 238.9±35.0 °C(Predicted)
• PKA: 6.77±0.40(Predicted)
• PSA: 63.63000
• Density: 1.208
• LogP: 0.15070
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 147.03539970
• Heavy Atom Count: 9
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

Thiazolidine-4-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CSCN1

Technology Process of Methyl thiazolidine-4-carboxylate

There total 4 articles about Methyl thiazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + (RS)-4-thiazolidinecarboxylic acid (444-27-9,19291-02-2,34592-47-7,45521-09-3,2756-91-4,6070-92-4,60731-25-1) → (4R)-thiazolidine-4-carboxylic acid,methyl ester (60667-24-5)

Guidance literature:

With thionyl chloride; a) RT, 12 h, b) reflux, 1 h;

DOI:10.1002/jhet.5570340607

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-cysteine methyl ester hydrochloride (18598-63-5) → (4R)-thiazolidine-4-carboxylic acid,methyl ester (60667-24-5)

Guidance literature:

With potassium acetate; In methanol; water; for 3.5h; Ambient temperature;

DOI:10.1002/prac.19973390118

Reference yield:

→ (4R)-thiazolidine-4-carboxylic acid,methyl ester (60667-24-5)

Guidance literature:

upstream raw materials:

formaldehyd

L-cysteine methyl ester hydrochloride

methanol

(RS)-4-thiazolidinecarboxylic acid

Downstream raw materials:

4-thiazolecarboxylate methyl ester

Refernces

• 1、 Mensching, Sabine,Kalesse, Markus. "Generation of thiazoles by column dehydrogenation of thiazolidines with MnO2". . p. 96 - 97. Retrieved 2007/10/03.
• 2、 -. "[4R]-3-(Omega-AROYLPROPIONYL)-4-THIAZOLIDINECARBOXYLIC ACIDS AND ESTERS". . . Retrieved 2008/06/13.