4-Quinolinepropanoic acid, a-(benzoylamino)-1,2-dihydro-2-oxo-

Base Information

• Chemical Name: 4-Quinolinepropanoic acid, a-(benzoylamino)-1,2-dihydro-2-oxo-
• CAS No.: 90098-03-6
• Molecular Formula: C₁₉H₁₆N₂O₄
• Molecular Weight: 336.347
• Mol file: 90098-03-6.mol

Synonyms:

Chemical Property of 4-Quinolinepropanoic acid, a-(benzoylamino)-1,2-dihydro-2-oxo-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Quinolinepropanoic acid, a-(benzoylamino)-1,2-dihydro-2-oxo-

There total 3 articles about 4-Quinolinepropanoic acid, a-(benzoylamino)-1,2-dihydro-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

benzoyl chloride (98-88-4) + 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3) → 2-Benzoylamino-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid (90098-03-6)

Guidance literature:

With potassium carbonate; In water; acetone;

DOI:10.1248/cpb.33.3775

Reference yield:

4-bromomethyl-2(1H)-quinolinone (4876-10-2) → 2-Benzoylamino-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid (90098-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / sodium / ethanol / 2 h

2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating

3: 54 percent / K₂CO₃ / acetone; H₂O

With hydrogenchloride; sodium; potassium carbonate; In ethanol; water; acetone;

DOI:10.1248/cpb.33.3775

Reference yield:

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester (4900-38-3) → 2-Benzoylamino-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid (90098-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 20 percent hydrochloric acid / 9 h / Heating

2: 54 percent / K₂CO₃ / acetone; H₂O

With hydrogenchloride; potassium carbonate; In water; acetone;

DOI:10.1248/cpb.33.3775

upstream raw materials:

benzoyl chloride

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride

4-bromomethyl-2(1H)-quinolinone

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

Refernces