2-Cyano-2-phenylvinylalcohol

Base Information

• Chemical Name: 2-Cyano-2-phenylvinylalcohol
• CAS No.: 5841-70-3
• Molecular Formula: C9H7NO
• Molecular Weight: 145.161
• Mol file: 5841-70-3.mol

Synonyms:Acetaldehyde,cyanophenyl- (6CI,7CI);Malonaldehydonitrile, phenyl- (8CI);(Formyl)(phenyl)acetonitrile;2-Formyl-2-phenylacetonitrile;3-Oxo-2-phenylpropanenitrile;Cyano(phenyl)acetaldehyde;NSC 403771;Phenylcyanoacetaldehyde;Phenylcyanoethanal;a-Cyanophenylacetaldehyde;a-Formylbenzeneacetonitrile;a-Formylphenylacetonitrile;Benzeneacetonitrile, α-formyl-;

Chemical Property of 2-Cyano-2-phenylvinylalcohol

Chemical Property:

• Vapor Pressure: 0.0335mmHg at 25°C
• Melting Point: 157-160 ºC
• Refractive Index: 1.535
• Boiling Point: 242.7 ºC at 760 mmHg
• Flash Point: 100.6 ºC
• PSA: 40.86000
• Density: 1.114 g/cm³
• LogP: 1.49268

Purity/Quality:

99% ^*data from raw suppliers

sodium(Z)-2-cyano-2-phenylethylenolate ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-2-phenylvinylalcohol

There total 12 articles about 2-Cyano-2-phenylvinylalcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenylacetonitrile (140-29-4) + formic acid ethyl ester (109-94-4) → phenyl(formyl)acetonitrile (5841-70-3)

Guidance literature:

With sodium hydride;

Reference yield: 80.0%

(Z)-2-phenyl-3-(piperidin-1-yl)acrylonitrile (57488-21-8) → phenyl(formyl)acetonitrile (5841-70-3)

Guidance literature:

With hydrogenchloride; In water; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1246/cl.2013.40

Reference yield: 63.0%

(Z)-2-phenyl-3-(p-tolylamino)acrylonitrile (31881-80-8) → phenyl(formyl)acetonitrile (5841-70-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 40 ℃; for 17h; Inert atmosphere;

DOI:10.1002/adsc.201400973

upstream raw materials:

diethyl ether

sodium ethanolate

phenylacetonitrile

formic acid ethyl ester

Downstream raw materials:

2-phenyl-3-propoxy-acrylonitrile

3-phenyl-7-methoxycoumarin

2-phenylmaleic anhydride

3-[2]naphthylamino-2-phenyl-acrylonitrile

Refernces

• 1、 -. "PHARMACEUTICAL COMPOUND". Page/Page column 92. . Retrieved 2016/03/14.
• 2、 Mamta,Aggarwal, Ranjana,Smith, Jessie,Sadana, Rachna. "Synthesis and cytotoxic evaluation of some new 1-(6- chloropyridazin-3-Yl)-3-H/Alkyl-4-phenyl-1H-pyrazol- 5-amines and their derivatives". . p. 59 - 68. Retrieved 2019/01/18.