Benzaldehyde, 2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methyl-

Base Information

• Chemical Name: Benzaldehyde, 2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methyl-
• CAS No.: 90163-04-5
• Molecular Formula: C13H13NO4
• Molecular Weight: 247.251
• Mol file: 90163-04-5.mol

Synonyms:

Chemical Property of Benzaldehyde, 2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methyl-

There total 1 articles about Benzaldehyde, 2-(2,5-dioxo-1-pyrrolidinyl)-5-methoxy-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Succinimide (123-56-8,89963-74-6) + (2-Bromo-5-methoxy-4-methyl-phenyl)-methanol (57295-33-7) → 2-Brom-5-methoxy-4-methylbenzaldehyd (57295-32-6) + 3-methoxy-4-methylbenzaldehyde (24973-22-6) + N-(2-Formyl-4-methoxy-5-methylphenyl)succinimid (90163-04-5)

Guidance literature:

With copper(l) iodide; sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1) dimethylacetamide, 2.,5-3 h, r.t., 2) 6 h, reflux;

DOI:10.1002/jlac.198519850712

Reference yield: 95.0%

N-(2-Formyl-4-methoxy-5-methylphenyl)succinimid (90163-04-5) → N-(2-Hydroxymethyl-4-methoxy-5-methylphenyl)succinimid (90163-05-6)

Guidance literature:

With methyl orange; sodium cyanoborohydride; In tetrahydrofuran; water; for 1h;

DOI:10.1002/jlac.198519850712

Reference yield:

N-(2-Formyl-4-methoxy-5-methylphenyl)succinimid (90163-04-5) → N-(2-Brommethyl-4-methoxy-5-methylphenyl)succinimid (90173-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 0,1percent methylorange, NaBH₃CN / tetrahydrofuran; H₂O / 1 h

2: 97 percent / triphenylphosphane, dibromohexachloroethane / 1,2-dichloro-ethane / 2.5 h / -20 - -18 °C

With dibromohexachloroethane; methyl orange; sodium cyanoborohydride; triphenylphosphine; In tetrahydrofuran; water; 1,2-dichloro-ethane;

DOI:10.1002/jlac.198519850712

upstream raw materials:

Succinimide

(2-Bromo-5-methoxy-4-methyl-phenyl)-methanol

Downstream raw materials:

N-(2-Hydroxymethyl-4-methoxy-5-methylphenyl)succinimid

N-(2-Brommethyl-4-methoxy-5-methylphenyl)succinimid

<2-(2,5-Dioxo-1-pyrrolidinyl)-3-methoxy-4-methylbenzyl>triphenylphosphonium-bromid

Refernces