Technology Process of 1H-Indole-5-carboximidamide,
2-[4-[4-(aminoiminomethyl)phenoxy]phenyl]-, dihydrochloride
There total 13 articles about 1H-Indole-5-carboximidamide,
2-[4-[4-(aminoiminomethyl)phenoxy]phenyl]-, dihydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-<4-(4-Cyanphenoxy)phenyl>indol-5-carbonitril;
With
hydrogenchloride;
In
ethanol; chloroform;
at 20 ℃;
for 20h;
With
ammonia;
In
ethanol;
at 20 ℃;
for 48h;
With
hydrogenchloride;
In
diethyl ether; ethanol;
for 0.5h;
DOI:10.3987/COM-08-S(D)8
- Guidance literature:
-
Multi-step reaction with 4 steps
1: K2CO3 / dimethylformamide / 3 h / 155 - 160 °C
2: 12 percent / piperidine / 24 h / 100 °C
3: 77 percent / triethylphosphite / 20 h / Heating
4: 1) ethanol; 2) NH3 / 1) CHCl3; 2) ethanol
With
piperidine; ethanol; ammonia; potassium carbonate; triethyl phosphite;
In
N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 72 percent / K2CO3 / dimethylformamide / 3 h / 155 - 160 °C
2: 12 percent / piperidine / 24 h / 100 °C
3: 77 percent / triethylphosphite / 20 h / Heating
4: 1) ethanol; 2) NH3 / 1) CHCl3; 2) ethanol
With
piperidine; ethanol; ammonia; potassium carbonate; triethyl phosphite;
In
N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302