N,N'-Diethyloxamide

Base Information

• Chemical Name: N,N'-Diethyloxamide
• CAS No.: 615-84-9
• Molecular Formula: C6H12N2O2
• Molecular Weight: 144.173
• Hs Code.: 2924199090
• European Community (EC) Number: 210-451-7
• NSC Number: 243629
• UNII: Q2873RC85Q
• DSSTox Substance ID: DTXSID30210478
• Nikkaji Number: J134.794B
• Wikidata: Q15495022
• Mol file: 615-84-9.mol

Synonyms:N,N'-Diethyloxamide;615-84-9;NN'-Diethyloxamide;Ethanediamide, N,N'-diethyl-;N1,N2-diethyloxalamide;N,N-DIETHYLOXAMIDE;Q2873RC85Q;EINECS 210-451-7;NSC-243629;NSC243629;N,N'-Diethyloxalamide;N,N''-Diethyloxamide;N,N'-diethylethanediamide;Oxamide, N,N'-diethyl-;UNII-Q2873RC85Q;SCHEMBL3060269;DTXSID30210478;N1,N2-DIETHYLETHANEDIAMIDE;MFCD00043650;STK044301;AKOS003253022;ETHANEDIAMIDE, N1,N2-DIETHYL-;NSC 243629;N(1),N(2)-DIETHYLETHANEDIAMIDE;CS-0362445;FT-0675996;E87986;Q15495022

Chemical Property of N,N'-Diethyloxamide

Chemical Property:

• Melting Point: 174-175 °C
• Refractive Index: 1.4500 (estimate)
• Boiling Point: 262.78°C (rough estimate)
• PSA: 58.20000
• Density: 1.033 g/cm³
• LogP: 0.04040
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 144.089877630
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

NN''-Diethyloxamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNC(=O)C(=O)NCC

Technology Process of N,N'-Diethyloxamide

There total 7 articles about N,N'-Diethyloxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethylamine (75-04-7,85404-22-4) + oxalic acid diethyl ester (95-92-1) → N,N'-diethyloxamide (615-84-9)

Guidance literature:

In ethanol;

DOI:10.1023/A:1010383903327

Reference yield:

carbon monoxide (201230-82-2) + ethylamine (75-04-7,85404-22-4) → N,N'-diethylurea (623-76-7) + N,N'-diethyloxamide (615-84-9)

Guidance literature:

With oxygen; potassium carbonate; potassium iodide; palladium diacetate; In acetonitrile; at 95 ℃; for 3h; under 2052 Torr;

Reference yield:

→ N,N'-diethyloxamide (615-84-9)

Guidance literature:

With dihydrogen peroxide;

upstream raw materials:

ethylamine

oxalic acid diethyl ester

N,N'-diethyldithiooxamide

carbon monoxide

Downstream raw materials:

5-chloro-1-ethyl-2-methyl-1H-imidazole

5-chloro-1-ethyl-2-methyl-4-nitro-1H-imidazole

Refernces

• 1、 Kochergin,Aleksandrova,Tolvinskaya,Zhukova,Pukhal'skaya,Telegin,Pevnitskii,Korsunskii. "The synthesis and immunotropic activity of a new azathioprine analog - 2-Amino-6-(1-ethyl-2-methyl-4-nitroimidazolyl-5-mercapto)purine". . p. 579 - 581. Retrieved 2007/10/03.
• 2、 Coe, Paul L.,Owen, Ian R.,Sellars, Alan. "Reactions of Tetrafluoroethylene Oligomers. Part 9. Some Reactions of Perfluoro(1-ethyl-1-methylpropyl)(s-butyl)ethanolide (an α-Lactone)". . p. 1097 - 1103. Retrieved 2007/10/02.